Title:
METHYLPIPERIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/005755
Kind Code:
A1
Abstract:
A compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which acts relying on an orexin (OX) receptor antagonistic activity and is useful for the treatment or prevention of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, head ache, migraine, pain, gastrointestinal diseases, epilepsy, inflammations, immune-related diseases, endocrine-related diseases and hypertension.
Inventors:
ABE MASAHITO (JP)
FUTAMURA AYA (JP)
SUZUKI RYO (JP)
NOZAWA DAI (JP)
OHTA HIROSHI (JP)
ARAKI YUKO (JP)
FUTAMURA AYA (JP)
SUZUKI RYO (JP)
NOZAWA DAI (JP)
OHTA HIROSHI (JP)
ARAKI YUKO (JP)
Application Number:
PCT/JP2012/067038
Publication Date:
January 10, 2013
Filing Date:
July 04, 2012
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
ABE MASAHITO (JP)
FUTAMURA AYA (JP)
SUZUKI RYO (JP)
NOZAWA DAI (JP)
OHTA HIROSHI (JP)
ARAKI YUKO (JP)
ABE MASAHITO (JP)
FUTAMURA AYA (JP)
SUZUKI RYO (JP)
NOZAWA DAI (JP)
OHTA HIROSHI (JP)
ARAKI YUKO (JP)
International Classes:
C07D413/14; A61K31/454; A61K31/4545; A61K31/506; A61P1/00; A61P5/00; A61P9/12; A61P25/04; A61P25/08; A61P25/16; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P37/00; A61P43/00; C07D498/04
Domestic Patent References:
| WO2010048012A1 | 2010-04-29 | |||
| WO2010048010A1 | 2010-04-29 | |||
| WO2008147518A1 | 2008-12-04 | |||
| WO2008147518A1 | 2008-12-04 | |||
| WO2010048010A1 | 2010-04-29 | |||
| WO2010048012A1 | 2010-04-29 |
Other References:
ZHU Y ET AL., J. PHARMACOL. SCI., vol. 92, 2003, pages 259 - 266
ZEITZER JM ET AL., TRENDS PHARMACOL. SCI., vol. 27, 2006, pages 368 - 374
MARCUS JN ET AL., J. COMP. NEUROL, vol. 435, 2001, pages 6 - 25
TRIVEDI JP ET AL., FEBS LETT, vol. 438, 1998, pages 71 - 75
YAMANAKA A ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 290, 2002, pages 1237 - 1245
HAGAN JJ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 10911 - 10916
NAKAMURA T ET AL., BRAIN RES., vol. 873, 2000, pages 181 - 187
SMITH MI ET AL., NEUROSCI. LETT., vol. 341, 2003, pages 256 - 258
BRISBARE-ROCH C ET AL., NAT. MED., vol. 13, 2007, pages 150 - 155
COX CD ET AL., J. MED. CHEM., vol. 53, 2010, pages 5320 - 5332
JOHN G ET AL., CHEMMEDCHEM., vol. 5, 2010, pages 1197 - 1214
TOSHIKATSU OKUMURA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, 2001, pages 976 - 981
See also references of EP 2730573A4
ZEITZER JM ET AL., TRENDS PHARMACOL. SCI., vol. 27, 2006, pages 368 - 374
MARCUS JN ET AL., J. COMP. NEUROL, vol. 435, 2001, pages 6 - 25
TRIVEDI JP ET AL., FEBS LETT, vol. 438, 1998, pages 71 - 75
YAMANAKA A ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 290, 2002, pages 1237 - 1245
HAGAN JJ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 10911 - 10916
NAKAMURA T ET AL., BRAIN RES., vol. 873, 2000, pages 181 - 187
SMITH MI ET AL., NEUROSCI. LETT., vol. 341, 2003, pages 256 - 258
BRISBARE-ROCH C ET AL., NAT. MED., vol. 13, 2007, pages 150 - 155
COX CD ET AL., J. MED. CHEM., vol. 53, 2010, pages 5320 - 5332
JOHN G ET AL., CHEMMEDCHEM., vol. 5, 2010, pages 1197 - 1214
TOSHIKATSU OKUMURA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, 2001, pages 976 - 981
See also references of EP 2730573A4
Attorney, Agent or Firm:
ASAMURA Kiyoshi et al. (JP)
Hiroshi Asamura (JP)
Hiroshi Asamura (JP)
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Claims: