Title:
MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT
Document Type and Number:
WIPO Patent Application WO/2017/041720
Kind Code:
A1
Abstract:
Disclosed are a mevalonate pathway inhibitor as a vaccine adjuvant, and use thereof. Specifically, the inhibitor is an acetoacetyl-CoA transferase inhibitor, an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor, and a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition，and the composition contains the mevalonate pathway inhibitor as an adjuvant.
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Inventors:
ZHANG YONGHUI (CN)
XIA YUN (CN)
XIE YONGHUA (CN)
YU ZHENGSEN (CN)
ZHOU XIAOYING (CN)
LI XIN (CN)
LI LIPING (CN)
YANG YUNYUN (CN)
GAO KANZHAO (CN)
WANG KE (CN)
LIU WANLI (CN)
ZHAO MENG (CN)
XIA YUN (CN)
XIE YONGHUA (CN)
YU ZHENGSEN (CN)
ZHOU XIAOYING (CN)
LI XIN (CN)
LI LIPING (CN)
YANG YUNYUN (CN)
GAO KANZHAO (CN)
WANG KE (CN)
LIU WANLI (CN)
ZHAO MENG (CN)
Application Number:
PCT/CN2016/098371
Publication Date:
March 16, 2017
Filing Date:
September 08, 2016
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
A61K31/675; A61K31/663; A61P31/04; A61P31/10; A61P33/00; A61P33/06; A61P35/00; A61P35/02; A61P37/02; C07F9/58; C07F9/6506; C07F9/6561
Domestic Patent References:
| WO2010033978A2 | 2010-03-25 | |||
| WO2002098354A2 | 2002-12-12 | |||
| WO2011147038A1 | 2011-12-01 |
Foreign References:
| CN102659840A | 2012-09-12 | |||
| CN1555271A | 2004-12-15 |
Other References:
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MARTIN, M.B. ET AL.: "Activity of Bisphosphonates against Trypanosoma brucei rhodesiense", J. MED. CHEM., vol. 45, 5 June 2002 (2002-06-05), pages 2904 - 2914, XP055069777
SZABO, C.M. ET AL.: "An Investigation of Bone Resorption and Dictyostelium discoideum Growth Inhibition by Bisphosphonate Drugs", J. MED. CHEM., vol. 45, no. 14, 8 June 2002 (2002-06-08), pages 2894 - 2903, XP002293541
SCHUTTER, J.W.D. ET AL.: "Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls", BIOORG. MED. CHEM., vol. 20, 24 July 2012 (2012-07-24), pages 5583 - 5591, XP028938220
SCHUTTER, J.W.D. ET AL.: "Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase", BIOORG. MED. CHEM. LETT., vol. 20, 11 August 2010 (2010-08-11), pages 5781 - 5786, XP027273561
CHEN, C.K.M. ET AL.: "Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase", J. MED. CHEM., vol. 51, no. 18, 23 August 2008 (2008-08-23), pages 5594 - 5607, XP009508957
MARTIN, M.B. ET AL.: "Activity of Bisphosphonates against Trypanosoma brucei rhodesiense", J. MED. CHEM., vol. 45, 5 June 2002 (2002-06-05), pages 2904 - 2914, XP055069777
SZABO, C.M. ET AL.: "An Investigation of Bone Resorption and Dictyostelium discoideum Growth Inhibition by Bisphosphonate Drugs", J. MED. CHEM., vol. 45, no. 14, 8 June 2002 (2002-06-08), pages 2894 - 2903, XP002293541
SCHUTTER, J.W.D. ET AL.: "Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls", BIOORG. MED. CHEM., vol. 20, 24 July 2012 (2012-07-24), pages 5583 - 5591, XP028938220
SCHUTTER, J.W.D. ET AL.: "Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase", BIOORG. MED. CHEM. LETT., vol. 20, 11 August 2010 (2010-08-11), pages 5781 - 5786, XP027273561
CHEN, C.K.M. ET AL.: "Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase", J. MED. CHEM., vol. 51, no. 18, 23 August 2008 (2008-08-23), pages 5594 - 5607, XP009508957
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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