Title:
MICACOCIDIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1997/029096
Kind Code:
A1
Abstract:
Novel compounds having various biological activities useful as drugs and animal drugs. Compounds represented by general formula (I) and salts or metal complexes thereof, wherein R1 represents COOR4, CONR5R6, CO-R7-OR or CH2OR8; R2 represents hydrogen, alkyl, aralkyl, heteroaryl, heteroaryl-alkyl, COR13, COOR14 or CONR15R16; R3 represents oxygen or OR3'; and the broken line (- - -) represents the presence of a double bond when R3 is oxygen, or the absence of a double bond when R3 is OR3'.
Inventors:
HAYASE YOSHIO (JP)
KOBAYASHI SHINOBU (JP)
UEDA KAZUO (JP)
HIDAKA SHIGETADA (JP)
KOBAYASHI SHINOBU (JP)
UEDA KAZUO (JP)
HIDAKA SHIGETADA (JP)
Application Number:
PCT/JP1997/000266
Publication Date:
August 14, 1997
Filing Date:
February 04, 1997
Export Citation:
Assignee:
SHIONOGI & CO (JP)
HAYASE YOSHIO (JP)
KOBAYASHI SHINOBU (JP)
UEDA KAZUO (JP)
HIDAKA SHIGETADA (JP)
HAYASE YOSHIO (JP)
KOBAYASHI SHINOBU (JP)
UEDA KAZUO (JP)
HIDAKA SHIGETADA (JP)
International Classes:
C07D277/10; C07D277/12; C07K5/078; C12P17/16; (IPC1-7): C07D277/10; A61K31/425; C07D277/12; C12P17/16
Domestic Patent References:
| WO1996004262A1 | 1996-02-15 |
Other References:
MOLECULAR MICROBIOLOGY, Vol. 13, No. 2, (1994), RAKIN ALEXANDER et al., "The Pesticin Receptor of Yersinia Enterocolitica: a Novel Virulence Factor With Dual Function", pages 253-263.
SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUCTS SYMPOSIUM PAPERS, 38th, (1996), AKIRA INO et al., "Chemical Structure and Total Synthesis of Novel Antimycoplasma Antibiotic Agent Micacocidin", pages 121-126.
SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUCTS SYMPOSIUM PAPERS, 38th, (1996), KOJIRO KIKUCHI et al., "Novel Alkaloid Ulbactins Produced by Marine Bacteria", pages 427-432.
See also references of EP 0976741A4
SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUCTS SYMPOSIUM PAPERS, 38th, (1996), AKIRA INO et al., "Chemical Structure and Total Synthesis of Novel Antimycoplasma Antibiotic Agent Micacocidin", pages 121-126.
SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUCTS SYMPOSIUM PAPERS, 38th, (1996), KOJIRO KIKUCHI et al., "Novel Alkaloid Ulbactins Produced by Marine Bacteria", pages 427-432.
See also references of EP 0976741A4
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