Title:
MICRO SOLID PHASE EXTRACTION DEVICES AND METHODS
Document Type and Number:
WIPO Patent Application WO/2019/224702
Kind Code:
A3
Abstract:
Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
Inventors:
GILAR MARTIN (US)
MCDONALD THOMAS S (US)
MICHIENZI JOSEPH D (US)
MUSACCHIO JEFFREY (US)
MUMMA RACHEL (US)
FADGEN KEITH (US)
GERHARDT GEOFF C (US)
MCDONALD THOMAS S (US)
MICHIENZI JOSEPH D (US)
MUSACCHIO JEFFREY (US)
MUMMA RACHEL (US)
FADGEN KEITH (US)
GERHARDT GEOFF C (US)
Application Number:
PCT/IB2019/054162
Publication Date:
January 16, 2020
Filing Date:
May 20, 2019
Export Citation:
Assignee:
WATERS TECHNOLOGIES CORP (US)
International Classes:
G01N30/06; B01D15/38; B01J20/00; G01N1/40; G01N30/54; G01N30/00; G01N30/60; G01N30/88
Foreign References:
| DE202016103304U1 | 2016-09-30 | |||
| US7722820B2 | 2010-05-25 | |||
| US20100081209A1 | 2010-04-01 |
Other References:
NÚRIA FONTANALS ET AL: "Overview of the novel sorbents available in solid-phase extraction to improve the capacity and selectivity of analytical determinations", CONTRIBUTIONS TO SCIENCE, vol. 6, 1 January 2010 (2010-01-01), ES, pages 199 - 213, XP055516579, ISSN: 1575-6343, DOI: 10.2436/20.7010.01.97
MEDINA-CASANELLAS SILVIA ET AL: "Preparation and evaluation of an immunoaffinity sorbent with Fab' antibody fragments for the analysis of opioid peptides by on-line immunoaffinity solid-phase extraction capillary electrophoresis-mass spec", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 789, 26 June 2013 (2013-06-26), pages 91 - 99, XP028676684, ISSN: 0003-2670, DOI: 10.1016/J.ACA.2013.06.030
HAHN R ET AL: "Comparison of protein A affinity sorbents", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 790, no. 1-2, 25 June 2003 (2003-06-25), pages 35 - 51, XP004426787, ISSN: 1570-0232, DOI: 10.1016/S1570-0232(03)00092-8
MEDINA-CASANELLAS SILVIA ET AL: "Preparation and evaluation of an immunoaffinity sorbent with Fab' antibody fragments for the analysis of opioid peptides by on-line immunoaffinity solid-phase extraction capillary electrophoresis-mass spec", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 789, 26 June 2013 (2013-06-26), pages 91 - 99, XP028676684, ISSN: 0003-2670, DOI: 10.1016/J.ACA.2013.06.030
HAHN R ET AL: "Comparison of protein A affinity sorbents", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 790, no. 1-2, 25 June 2003 (2003-06-25), pages 35 - 51, XP004426787, ISSN: 1570-0232, DOI: 10.1016/S1570-0232(03)00092-8
Attorney, Agent or Firm:
VERNON, Deborah M. (US)
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