Title:
MICROBIAL DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO2001066136
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity.
Inventors:
CAPLAN MICHAEL
Application Number:
PCT/US2000/033121
Publication Date:
December 27, 2001
Filing Date:
December 06, 2000
Export Citation:
Assignee:
PANACEA PHARM LLC (US)
International Classes:
A61K39/02; A61K39/00; A61K39/002; A61K39/12; A61K39/35; A61P37/08; (IPC1-7): A61K39/00; A61K39/35; A61K35/66; A61P37/08
Domestic Patent References:
| WO1999025387A1 | 1999-05-27 | |||
| WO1999038978A1 | 1999-08-05 | |||
| WO2000054803A2 | 2000-09-21 |
Foreign References:
| US5888799A | 1999-03-30 | |||
| US5830463A | 1998-11-03 | |||
| US5389368A | 1995-02-14 |
Other References:
MEDAGLINI, D. ET AL: "Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1995) VOL. 92, NO. 15, PP. 6868-6872., XP002177838
VRTALA S ET AL: "Humoral immune responses to recombinant tree pollen allergens (Bet v I and Bet v II) in mice: construction of a live oral allergy vaccine.", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (1995 MAY-JUN) 107 (1-3) 290-4. REF: 15, XP001024439
VRTALA S ET AL: "Humoral immune responses to recombinant tree pollen allergens (Bet v I and Bet v II) in mice: construction of a live oral allergy vaccine.", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, (1995 MAY-JUN) 107 (1-3) 290-4. REF: 15, XP001024439
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