Title:
MICROCAPSULE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN PREVENTING AND/OR TREATING DAMAGE TO SALIVARY GLANDS CAUSED BY RADIATION THERAPY
Document Type and Number:
WIPO Patent Application WO/2023/019950
Kind Code:
A1
Abstract:
A microcapsule containing vitamin C and nitrate, said capsule comprising a wall material and a core material encapsulated in the wall material. The wall material comprises pectin and sodium carboxymethyl cellulose, and the core material comprises vitamin C, nitrate, and chitosan. The raw materials of the microcapsule comprise, in parts by weight: pectin 0.7-1.2 parts by weight, sodium carboxymethyl cellulose 0.7-1.2 parts by weight, chitosan 1 part by weight, and vitamin C and nitrate in a total amount of 0.3-1.2 parts by weight, the molar ratio of vitamin C to nitrate ions being 1:1-1:5. A use of the microcapsule in the preparation of a drug for preventing and/or treating damage to the salivary glands caused by radiation therapy, in particular a use in the preparation of a drug for preventing and/or treating damage to the salivary glands caused by radiation therapy for nasopharyngeal carcinoma.
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Inventors:
WANG SONGLING (CN)
WANG YUJI (CN)
LI WENBIN (CN)
FENG XIAOYU (CN)
PAN WEN (CN)
WU ZHIFANG (CN)
ZHOU JIAN (CN)
WANG YUJI (CN)
LI WENBIN (CN)
FENG XIAOYU (CN)
PAN WEN (CN)
WU ZHIFANG (CN)
ZHOU JIAN (CN)
Application Number:
PCT/CN2022/083010
Publication Date:
February 23, 2023
Filing Date:
March 25, 2022
Export Citation:
Assignee:
CAPITAL MEDICAL UNIV (CN)
BEIJING STOMATOLOGICAL HOSPITAL CAPITAL MEDICAL UNIV (CN)
BEIJING STOMATOLOGICAL HOSPITAL CAPITAL MEDICAL UNIV (CN)
International Classes:
A61K9/52; A61K31/375; A61K33/00; A61K47/38; A61P1/02
Foreign References:
| CN113398098A | 2021-09-17 | |||
| CN113398093A | 2021-09-17 | |||
| CN110327367A | 2019-10-15 | |||
| CN105878271A | 2016-08-24 | |||
| CN110025638A | 2019-07-19 | |||
| CN112516159A | 2021-03-19 | |||
| EP2862447A1 | 2015-04-22 | |||
| KR20030077260A | 2003-10-01 |
Other References:
CHANG, SHIMIN ET AL.: "Study on Inorganic Nitrate Preventing Radiation Injury of Submandibular Gland in Mice", 2017 NATIONAL ORAL BIOMEDICAL ACADEMIC ANNUAL CONFERENCE THESES COLLECTION, 13 October 2017 (2017-10-13)
LU, BIN ET AL.: "Preparation Technology of Microcapsules and Microspheres", NEW TECHNIQUES AND NEW DOSAGE FORMS OF DRUGS, 31 July 2005 (2005-07-31)
LU, BIN ET AL.: "Preparation Technology of Microcapsules and Microspheres", NEW TECHNIQUES AND NEW DOSAGE FORMS OF DRUGS, 31 July 2005 (2005-07-31)
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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