Title:
MICROCRYSTALLINE CELLULOSE AND CALCIUM PHOSPHATE COMPOSITIONS USEFUL AS PHARMACEUTICAL EXCIPIENTS
Document Type and Number:
WIPO Patent Application WO/2011/056775
Kind Code:
A3
Abstract:
Coprocessed compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained by preparing aqueous slurries of microcrystalline cellulose and calcium phosphate and drying such slurries to produce particulate products. The coprocessed products exhibit improved compactibility, as compared to dry physical blends of the same components.
Inventors:
THOORENS GREGORY (BE)
LECLERCQ BRUNO (BY)
RUSZKAY THOMAS (US)
LECLERCQ BRUNO (BY)
RUSZKAY THOMAS (US)
Application Number:
PCT/US2010/055068
Publication Date:
November 03, 2011
Filing Date:
November 02, 2010
Export Citation:
Assignee:
FMC CORP (US)
THOORENS GREGORY (BE)
LECLERCQ BRUNO (BY)
RUSZKAY THOMAS (US)
THOORENS GREGORY (BE)
LECLERCQ BRUNO (BY)
RUSZKAY THOMAS (US)
International Classes:
A61K47/04; A61K9/16; A61K9/20; A61K47/02; A61K47/30; A61K47/38
Foreign References:
| US4744987A | 1988-05-17 | |||
| US6123964A | 2000-09-26 | |||
| US20020176889A1 | 2002-11-28 | |||
| US6103260A | 2000-08-15 | |||
| US20030185891A1 | 2003-10-02 | |||
| EP0124027A1 | 1984-11-07 |
Other References:
See also references of EP 2496261A4
Attorney, Agent or Firm:
BOLAND, Kevin, J. et al. (1735 Market StreetPhiladelphia, PA, US)
Download PDF:
Previous Patent: COMPACT ANTENNA
Next Patent: WEDGE POSITIONING APPARATUS FOR JET PUMP ASSEMBLIES IN NUCLEAR REACTORS
Next Patent: WEDGE POSITIONING APPARATUS FOR JET PUMP ASSEMBLIES IN NUCLEAR REACTORS