Title:
MICROFABRICATED MEMBRANES AND MATRICES
Document Type and Number:
WIPO Patent Application WO2000047129
Kind Code:
A3
Abstract:
The invention relates to microfabricated membranes and matrices that have a highly controlled and complex three-dimensional topography. The new microfabricated membranes and matrices can be prepared of man-made as well as natural materials, such as materials found in naturally occurring membranes, and thus can be made in the form of tissue substitutes or analogs, such as basal lamina, dermal, or skin analogs.
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Inventors:
MORGAN JEFFREY R
PINS GEORGE D
PINS GEORGE D
Application Number:
PCT/US2000/003427
Publication Date:
February 15, 2001
Filing Date:
February 10, 2000
Export Citation:
Assignee:
GEN HOSPITAL CORP (US)
International Classes:
A61L15/24; A61L15/26; A61L15/32; A61L15/42; C12N5/08; (IPC1-7): A61L27/00; A61F2/10
Foreign References:
| US5273900A | 1993-12-28 |
Other References:
FLEMMING R.C. ET AL.: "Effects of Synthetic Micro- and Nano-Structured Surfaces on Cell Behavior", BIOMATERIALS,, vol. 20, March 1999 (1999-03-01), pages 573 - 588, XP002926697
BOYCE ET AL.: "Structure of a Collagen-CaG Dermal Skin Substitute Optimized for Cultured Human Epiderman Keratinocytes", J. BIOMED. MAT. RES.,, vol. 22, October 1988 (1988-10-01), pages 939 - 957, XP002926698
DALTON ET AL.: "Modulation of Corneal Epithelial Stratification by Polymer Surface Topography", J. BIOMED. MAT. RES.,, vol. 45, June 1999 (1999-06-01), pages 384 - 394, XP002926699
FITTON ET AL.: "Surface Topography Can Interfere with Epithelial Tissue Migration", J. BOIMED. MAT. RES.,, vol. 42, November 1998 (1998-11-01), pages 245 - 257, XP002926700
GOODMAN ET AL.: "Three-Dimensional Extracellular Matrix Textured Biomaterials", BIOMATERIALS,, vol. 17, November 1996 (1996-11-01), pages 2087 - 2095, XP002927444
BOYCE ET AL.: "Structure of a Collagen-CaG Dermal Skin Substitute Optimized for Cultured Human Epiderman Keratinocytes", J. BIOMED. MAT. RES.,, vol. 22, October 1988 (1988-10-01), pages 939 - 957, XP002926698
DALTON ET AL.: "Modulation of Corneal Epithelial Stratification by Polymer Surface Topography", J. BIOMED. MAT. RES.,, vol. 45, June 1999 (1999-06-01), pages 384 - 394, XP002926699
FITTON ET AL.: "Surface Topography Can Interfere with Epithelial Tissue Migration", J. BOIMED. MAT. RES.,, vol. 42, November 1998 (1998-11-01), pages 245 - 257, XP002926700
GOODMAN ET AL.: "Three-Dimensional Extracellular Matrix Textured Biomaterials", BIOMATERIALS,, vol. 17, November 1996 (1996-11-01), pages 2087 - 2095, XP002927444
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