Title:
MICRORNA-29 COMPOUNDS, COMPOSITIONS AND USES IN THERAPY
Document Type and Number:
WIPO Patent Application WO/2022/084561
Kind Code:
A3
Abstract:
This invention relates to novel microRNA-29 (miR-29) compounds, compositions comprising the same, and their use in therapy. In particular, provided herein are miR-29 compounds and compositions that are particularly effective and safe in the treatment of diseases that involve localised collagen dysregulation, such as tendon damage including tendinopathy, and tissue fibrosis including Peyronie's disease and Dupuytren's disease. Also provided are advantageous dosages and treatment regimens for miR-29 compounds.
Inventors:
GILCHRIST DEREK STEWART (GB)
MILLAR NEAL LINDSAY (GB)
MILLAR NEAL LINDSAY (GB)
Application Number:
PCT/EP2021/079580
Publication Date:
June 02, 2022
Filing Date:
October 25, 2021
Export Citation:
Assignee:
CAUSEWAY THERAPEUTICS LTD (GB)
International Classes:
C12N15/113; A61K31/713; A61P19/00
Domestic Patent References:
| WO2016040373A1 | 2016-03-17 | |||
| WO2016142703A1 | 2016-09-15 |
Other References:
YANG YA-LING ET AL: "Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 10, 21 May 2020 (2020-05-21), pages 3636, XP055885309, DOI: 10.3390/ijms21103636
Attorney, Agent or Firm:
WISE, Daniel Joseph et al. (GB)
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