Title:
MICROSTRUCTURE COMPRISING MICRONEEDLE AND DRUG FOR WOUND HEALING
Document Type and Number:
WIPO Patent Application WO/2022/071748
Kind Code:
A1
Abstract:
The present invention relates to a microstructure comprising: a microneedle; and a drug for wound healing, contained therein. The microstructure according to an aspect of the present invention comprises a wound-healing drug containing tranilast inside a microneedle, and thus, as compared to a microneedle that is not treated or a microneedle that does not contain a drug, has better wound-healing effects when used to treat wounded skin, such as reduced thicknesses of a dermal layer and a fibrous layer, significantly increased blood vessel formation, reduced collagen density, and reduced expression of fibrotic factors such as type 1 collagen and SMA, and inflammatory factors such as TGF-beta.
Inventors:
HEO CHAN YEONG (KR)
NAM SUN-YOUNG (KR)
JEONG JAE HEON (KR)
JEONG JI HOON (KR)
NAM SUN-YOUNG (KR)
JEONG JAE HEON (KR)
JEONG JI HOON (KR)
Application Number:
PCT/KR2021/013333
Publication Date:
April 07, 2022
Filing Date:
September 29, 2021
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
RESEARCH ＆ BUSINESS FOUNDATION SUNGKYUNKWAN UNIV (KR)
RESEARCH ＆ BUSINESS FOUNDATION SUNGKYUNKWAN UNIV (KR)
International Classes:
A61K9/00; A61K31/196; A61K47/34; A61M37/00; A61P17/02
Foreign References:
| KR20170104387A | 2017-09-15 | |||
| JP2003119132A | 2003-04-23 | |||
| JP2009114153A | 2009-05-28 | |||
| KR20200043205A | 2020-04-27 |
Other References:
AMINI-NIK SAEID; YOUSUF YUSEF; JESCHKE MARC G.: "Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions", ADVANCED DRUG DELIVERY REVIEWS, vol. 123, 1 January 1900 (1900-01-01), Amsterdam , NL , pages 135 - 154, XP085317627, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.017
SADAYUKI SHIGEKI , TERUO MARAKAMI , NOBORU YATA , YOSHIKAZU IKUTA : "Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast", JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, vol. 31, no. 2, 1 January 1997 (1997-01-01), SE , pages 151 - 158, XP008073494, ISSN: 0284-4311, DOI: 10.3109/02844319709085482
SADAYUKI SHIGEKI , TERUO MARAKAMI , NOBORU YATA , YOSHIKAZU IKUTA : "Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast", JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, vol. 31, no. 2, 1 January 1997 (1997-01-01), SE , pages 151 - 158, XP008073494, ISSN: 0284-4311, DOI: 10.3109/02844319709085482
Attorney, Agent or Firm:
CHOI, Woo-sung (KR)
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