Title:
MIRNA INHIBITOR FOR HDAC4 SIGNALING PATHWAY AND OVEREXPRESSION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/227687
Kind Code:
A1
Abstract:
Provided are the use of miRNA as a HDAC4 signaling pathway inhibitor, a HDAC4 signaling pathway inhibitor comprising the miRNA, and an overexpression method and the use thereof, wherein the miRNA comprises miR-1281. The miRNA targets HDAC4 and inhibits the activity of the HDAC4 signaling pathway by inhibiting the HDAC4 gene expression, wherein same has the function as the HDAC4 signaling pathway inhibitor.
Inventors:
QIAN ZHENGJIANG (CN)
LI XIANG (CN)
LI YANJIAO (CN)
LI XIANG (CN)
LI YANJIAO (CN)
Application Number:
PCT/CN2018/100938
Publication Date:
December 05, 2019
Filing Date:
August 17, 2018
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K31/7105; A61P1/00; A61P7/00; A61P9/00
Domestic Patent References:
| WO2009117418A2 | 2009-09-24 |
Foreign References:
| CN107312851A | 2017-11-03 |
Other References:
WANG XIANYAN ET AL: "microRNA-140", ONCOLOGY PROGRESS, vol. 14, no. 3, 20 March 2016 (2016-03-20), pages 223 - 227
AMODIO, N: "Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma", MOLECULAR CANCER THERAPEUTICS, vol. 15, no. 6, 30 June 2016 (2016-06-30), pages 1364 - 1375, XP055659374, ISSN: 1535-7163
AMODIO, N: "Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma", MOLECULAR CANCER THERAPEUTICS, vol. 15, no. 6, 30 June 2016 (2016-06-30), pages 1364 - 1375, XP055659374, ISSN: 1535-7163
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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