MITOTIC KINESIN INHIBITORS

Title:

MITOTIC KINESIN INHIBITORS

Document Type and Number:

WIPO Patent Application WO2003050064

Kind Code:

A3

Abstract:

The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

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Inventors:

FRALEY MARK E (US)
HARTMAN GEORGE D (US)
HOFFMAN WILLIAM F (US)

Application Number:

PCT/US2002/038417

Publication Date:

October 16, 2003

Filing Date:

December 02, 2002

Export Citation:

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Assignee:

MERCK & CO INC (US)
FRALEY MARK E (US)
HARTMAN GEORGE D (US)
HOFFMAN WILLIAM F (US)

International Classes:

A61K31/138; A61K31/337; A61K31/4465; A61K31/4535; A61K31/519; A61K31/551; A61K31/5513; A61K39/395; A61K45/00; A61P35/00; C07D495/04; C07D498/02; C07D519/00; (IPC1-7): C07D495/04; A61K31/519

Foreign References:

US5124331A	1992-06-23
EP0884310A1	1998-12-16

Other References: