Title:
MITOTIC KINESIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004039774
Kind Code:
A3
Abstract:
The present invention relates to azaquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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Inventors:
COLEMAN PAUL J (US)
FRALEY MARK E (US)
HOFFMAN WILLIAM F (US)
FRALEY MARK E (US)
HOFFMAN WILLIAM F (US)
Application Number:
PCT/US2003/015810
Publication Date:
July 01, 2004
Filing Date:
May 19, 2003
Export Citation:
Assignee:
MERCK & CO INC (US)
COLEMAN PAUL J (US)
FRALEY MARK E (US)
HOFFMAN WILLIAM F (US)
COLEMAN PAUL J (US)
FRALEY MARK E (US)
HOFFMAN WILLIAM F (US)
International Classes:
A61K31/4375; A61K31/519; C07D401/12; C07D403/12; C07D471/04; C07D487/02; C07D487/04; C07D; (IPC1-7): C07D401/12; A61K31/4375; C07D403/12; C07D487/04
Domestic Patent References:
| WO2002083143A1 | 2002-10-24 | |||
| WO2001019800A2 | 2001-03-22 |
Other References:
DATABASE CAPLUS [online] WAGNER E.: "Synthesis and biological evaluation of some derivatives of pyrido [3,2-d]pyrimidine", XP002976153, accession no. STN Database accession no. 1995:459424
DATABASE CAPLUS [online] BAYOUMY ET AL.: "New synthesis of pyridopyrimidine and pyridotetrahydroquinoline derivatives", XP002976154, accession no. STN Database accession no. 1992:151716
See also references of EP 1517904A4
DATABASE CAPLUS [online] BAYOUMY ET AL.: "New synthesis of pyridopyrimidine and pyridotetrahydroquinoline derivatives", XP002976154, accession no. STN Database accession no. 1992:151716
See also references of EP 1517904A4
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