Title:
MOB-5/HMOB-5 AS A CANCER DIAGNOSTIC MARKER
Document Type and Number:
WIPO Patent Application WO2001055170
Kind Code:
A9
Abstract:
The invention provides isolated nucleic acids comprising the nucleic acids set forth in the Sequence Listing as SEQ ID NO:1(corresponding to a cDNA encoding a rat Mob-5 protein), SEQ ID NO:3(corresponding to a cDNA encoding the cancer specific human Mob-5 protein homolog with an internal deletion of 53 amino acid residues, referred to as cMob-5.), SEQ ID NO:5(corresponding to a cDNA encoding a human Mob-5 protein), SEQ ID NO:7(corresponding to a nucleic acid encoding a rat Mob-5-AP fusion protein and SEQ ID NO:9(corresponding to a nucleic acid encoding a human Mob-5-AP fusion protein). The invention also provides purified polypeptides having the sequences set forth in the Sequence Listing as any of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8 and SEQ ID NO:10. This invention also relates to a method of detecting the presence of cancer in a patient comprising: a) contacting a sample from the patient with an antibody to Mob-5; and b) detecting the binding of the antibody with an antigen in the sample, wherein binding of antigen to the antibody indicates the presence of Mob-5 antigen in the sample and wherein Mob-5 antigen in the sample indicates the presence of cancer in the patient, thereby detecting the presence of cancer in the patient.
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Inventors:
LIANG PENG (US)
Application Number:
PCT/US2001/002680
Publication Date:
October 17, 2002
Filing Date:
January 26, 2001
Export Citation:
Assignee:
UNIV VANDERBILT (US)
LIANG PENG (US)
LIANG PENG (US)
International Classes:
C07K16/30; G01N33/574; (IPC1-7): C07H21/04; A61K38/00; A61K48/00; C07K16/00; G01N33/53
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