Title:
MODEL FOR NASH OR LIVER TUMOR, METHOD FOR PRODUCTION OF THE MODEL, METHOD FOR SCREENING OF THERAPEUTIC AGENT FOR NASH OR LIVER TUMOR, METHOD FOR ANALYSIS OF MECHANISM FOR DEVELOPMENT OF NASH OR LIVER TUMORM, AND AGENT FOR PREVENTION OR TREATMENT OF NASH
Document Type and Number:
WIPO Patent Application WO/2006/093143
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a model animal which can present a symptom distinctive for non-alcoholic steatohepatitis (NASH) within a short period of time without artificially deleting a gene originally expressed in 'a hepatocyte' or a model animal for liver tumor caused by NASH; the elucidation of the mechanism for development of NASH or liver tumor; screening of an agent for the prevention or treatment of NASH or liver tumor; and an agent for the prevention or treatment of NASH. [MEANS FOR SOLVING PROBLEMS] A model animal for non-alcoholic steatohepatitis or liver tumor having a gene encoding a part or the entire of the amino acid sequence for SREBP1c having a transcriptional activity and a promoter gene capable of directing an adipose tissue-specific expression introduced therein; and an agent for preventing or treating NASH, comprising one or more substances selected from adiponectin or an analogue thereof and a gene encoding adiponectin or the analogue thereof as the active ingredient(s).
Inventors:
NAKAYAMA HITOMI (JP)
OTABE SHUICHI (JP)
YAMADA KENTARO (JP)
UENO TAKATO (JP)
HIROTA NAOTOSHI (JP)
OTABE SHUICHI (JP)
YAMADA KENTARO (JP)
UENO TAKATO (JP)
HIROTA NAOTOSHI (JP)
Application Number:
PCT/JP2006/303742
Publication Date:
September 08, 2006
Filing Date:
February 28, 2006
Export Citation:
Assignee:
UNIV KURUME (JP)
NAKAYAMA HITOMI (JP)
OTABE SHUICHI (JP)
YAMADA KENTARO (JP)
UENO TAKATO (JP)
HIROTA NAOTOSHI (JP)
NAKAYAMA HITOMI (JP)
OTABE SHUICHI (JP)
YAMADA KENTARO (JP)
UENO TAKATO (JP)
HIROTA NAOTOSHI (JP)
International Classes:
C12N15/00; A01K67/027; A61K38/00; A61K48/00; A61P1/16; C12N15/09; G01N33/15; G01N33/50
Other References:
SHIMOMURA I. ET AL.: "Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue:model for congenital generalized lipodystrophy", GENES & DEVELOP., vol. 12, 1998, pages 3182 - 3194, XP002926780
TAGUCHI M. ET AL.: "Hi Alcohol-sei Shibokan", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 63, no. SPECIAL EXTRA ISSUE 2, 28 February 2005 (2005-02-28), pages 291 - 294, XP003002862
MARUYAMA H.: "NASH no Byori Soshikizo, Shindan to Hassei Kijo", IGAKU NO AYUMI, vol. 206, no. 5, 2 August 2003 (2003-08-02), pages 326 - 330, XP003002863
TAMURA S. ET AL.: "Adiponectin no Kan Sen'ika Oyobi Gan ni Okeru Igi", BIO CLINICA, vol. 19, no. 13, 10 December 2004 (2004-12-10), pages 29 - 34, XP003002864
TAGUCHI M. ET AL.: "Hi Alcohol-sei Shibokan", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 63, no. SPECIAL EXTRA ISSUE 2, 28 February 2005 (2005-02-28), pages 291 - 294, XP003002862
MARUYAMA H.: "NASH no Byori Soshikizo, Shindan to Hassei Kijo", IGAKU NO AYUMI, vol. 206, no. 5, 2 August 2003 (2003-08-02), pages 326 - 330, XP003002863
TAMURA S. ET AL.: "Adiponectin no Kan Sen'ika Oyobi Gan ni Okeru Igi", BIO CLINICA, vol. 19, no. 13, 10 December 2004 (2004-12-10), pages 29 - 34, XP003002864
Attorney, Agent or Firm:
Kijima, Tomoko (37-3-302 Takeya-cho, Takano, Sakyo-k, Kyoto City Kyoto, JP)
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