Title:
MODIFICATION AND USE OF SILK FIBROIN
Document Type and Number:
WIPO Patent Application WO/2023/206055
Kind Code:
A1
Abstract:
Provided are a modification and the use of silk fibroin. Calcium in silk fibroin or fibroin fibers is partially or completely removed, so as to obtain the modified silk fibroin with a broad-spectrum antioxidant effect. A method for preparing the modified silk fibroin, which method comprises: dissolving fibroin fibers by using a neutral salt solution, i.e., a calcium chloride-containing ternary solution and/or a lithium bromide solution, and performing desalting to obtain a silk fibroin solution; and adding a chelating agent to the silk fibroin solution for a full reaction, and performing a desalting treatment to obtain a low-calcium or calcium-free silk fibroin solution. The modified silk fibroin has the effects of broad-spectrum, stable and efficient removal of excessive active oxygen, and a burn dressing prepared therefrom has the effects of promoting wound healing, maintaining moisture, maintaining electrolyte balance, stopping bleeding, etc., when applied to a burn treatment. In addition, a new therapeutic strategy is provided for the treatment of acute and chronic inflammatory diseases caused by oxidative stress clinically.
Inventors:
PENG QIN (CN)
QIU JUHUI (CN)
QIAN ZHIYONG (CN)
QIU JUHUI (CN)
QIAN ZHIYONG (CN)
Application Number:
PCT/CN2022/089182
Publication Date:
November 02, 2023
Filing Date:
April 26, 2022
Export Citation:
Assignee:
SHENZHEN BAY LABORATORY (CN)
International Classes:
A61K38/17; C08H1/00; A61K47/42; A61L26/00; A61L27/22; A61L27/54; A61P29/00; A61P39/06
Foreign References:
| CN110903374A | 2020-03-24 | |||
| CN1566086A | 2005-01-19 | |||
| CN101700409A | 2010-05-05 | |||
| CN110152051A | 2019-08-23 | |||
| CN110975000A | 2020-04-10 |
Other References:
BAO LI-JUN; PENG YUN-WU; YIN CHUANG; SUN MIN-RUI; SHAANXI: "Studies on Polypeptide Antioxidant Activity of Natural Yellow Cocoon by Different Hydrolysis Methods", FOOD RESEARCH AND DEVELOPMENT, TIANJIN SHI SHIPIN YANJIUSUO, CN, vol. 38, no. 17, 30 September 2017 (2017-09-30), CN , pages 14 - 16 + 30, XP009549865, ISSN: 1005-6521
LIU ZHENZHU; LIU HONGBIN; DENG HUA; MA JUN; LI RUIXIN: "New Desalination Process Research on Soluble Silk Fibroin", SHUI-CHULI-JISHU : SHUANGYUEKAN = TECHNOLOGY OF WATER TREATMENT, HAIYANG CHUBANSHE, CN, vol. 43, no. 4, 30 April 2017 (2017-04-30), CN , pages 62 - 65, XP009549881, ISSN: 1000-3770, DOI: 10.16796/j.cnki.1000-3770.2017.04.014
LIU ZHENZHU; LIU HONGBIN; DENG HUA; MA JUN; LI RUIXIN: "New Desalination Process Research on Soluble Silk Fibroin", SHUI-CHULI-JISHU : SHUANGYUEKAN = TECHNOLOGY OF WATER TREATMENT, HAIYANG CHUBANSHE, CN, vol. 43, no. 4, 30 April 2017 (2017-04-30), CN , pages 62 - 65, XP009549881, ISSN: 1000-3770, DOI: 10.16796/j.cnki.1000-3770.2017.04.014
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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