MODIFIED CORYNEBACTERIUM MICROORGANISM, METHOD FOR CONSTRUCTING SAME AND USE THEREOF

Title:

MODIFIED CORYNEBACTERIUM MICROORGANISM, METHOD FOR CONSTRUCTING SAME AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/142859

Kind Code:

A1

Abstract:

The present invention relates to the technical field of microbial engineering, and in particular to a modified Corynebacterium microorganism, a method for constructing same and use thereof. The present invention provides use of weakening or inactivation of a non-essential gene in increasing microorganism threonine yield or constructing a microorganism producing threonine. The non-essential gene is cg1507-cg1524, Cgl1336-Cgl1352, or NCgl1281-NCgl1298. By means of inactivating the non-essential gene, the present invention significantly improves the threonine production capacity of the strain, and meanwhile, enhances the growth of the strain. The modification of the described non-essential gene can be used in threonine fermentation and production, and has good application value.

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Inventors:

KANG PEI (CN)
LIU TAO (CN)
GONG WEIBO (CN)
HE JUN (CN)
LI YAN (CN)

Application Number:

PCT/CN2022/143100

Publication Date:

August 03, 2023

Filing Date:

December 29, 2022

Export Citation:

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Assignee:

LANGFANG MEIHUA BIOTECHNOLOGY DEV CO LTD (CN)

International Classes:

C12P13/08; C12N1/21; C12N15/52; C12N15/53; C12N15/54; C12N15/60; C12N15/77; C12R1/15

Foreign References:

US20200181660A1

2020-06-11

Other References:

BAUMGART, M. ET AL.: "Construction of a Prophage-Free Variant of Corynebacterium Glutamicum ATCC 13032 for Use as a Platform Strain for Basic Research and Industrial Biotechnology", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 79, no. 19, 31 October 2013 (2013-10-31), XP055815382, DOI: 10.1128/AEM.01634-13

Attorney, Agent or Firm:

BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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