Title:
MODIFIED DEFENSINS AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2003070176
Kind Code:
A3
Abstract:
This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
Inventors:
MOSS JOEL (US)
HIRAYAMA TOSHIYA (JP)
WADA AKIHARO (JP)
LEVINE RODNEY L (US)
PAONE GREGORINO (IT)
HIRAYAMA TOSHIYA (JP)
WADA AKIHARO (JP)
LEVINE RODNEY L (US)
PAONE GREGORINO (IT)
Application Number:
PCT/US2003/004649
Publication Date:
November 27, 2003
Filing Date:
February 18, 2003
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
UNIV NAGASAKI (JP)
MOSS JOEL (US)
HIRAYAMA TOSHIYA (JP)
WADA AKIHARO (JP)
LEVINE RODNEY L (US)
PAONE GREGORINO (IT)
UNIV NAGASAKI (JP)
MOSS JOEL (US)
HIRAYAMA TOSHIYA (JP)
WADA AKIHARO (JP)
LEVINE RODNEY L (US)
PAONE GREGORINO (IT)
International Classes:
C07K14/47; A61K38/00; (IPC1-7): C07K14/475; A61K38/18
Other References:
PAONE ET AL.: "ADP ribosylation of human neutrophil peptide-1 regulates biological properties", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 12, 11 June 2002 (2002-06-11), pages 8231 - 8235, XP002966774
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