MODIFIED-EXTRACELLULAR MATRIX-BASED HYDROGEL, METHOD OF PREPARING SAME, AND USE OF SAME

WIPO Patent Application WO/2022/154245

A1

A modified-extracellular matrix-based hydrogel according to one example of the present invention comprises an extracellular matrix-modified collagen complex formed by a Michael addition reaction between an extracellular matrix having an amine group, and a modified collagen having an ethylenically unsaturated bond functional group introduced therein. The modified-extracellular matrix-based hydrogel according to the present invention exhibits enhanced mechanical properties (e.g. viscoelasticity). In addition, the preparation of a bio ink by encapsulating cells in the modified-extracellular matrix-based hydrogel according to the present invention exhibits high cell viability. In addition, transplantable artificial biological tissues (e.g. artificial corneal tissues) fabricated by 3-D printing the bio ink according to the present invention, when transplanted in a damaged cornea, can be sutured and have a transparency similar to a real cornea, and due to enhanced mechanical properties, are capable of reconstructing corneal tissues without other adverse side effects.

KIM HYEON JI (KR)
CHO DONG WOO (KR)
JANG JIN AH (KR)

PCT/KR2021/017390

July 21, 2022

November 24, 2021

Click for automatic bibliography generation  

POSTECH RES & BUSINESS DEV FOUND (KR)

A61L27/52; A61F2/14; A61L27/24; A61L27/36; A61L27/38

KR20160140494A	2016-12-07
KR20180125776A	2018-11-26
US20160193384A1	2016-07-07
US20200179563A1	2020-06-11

LEE JU WON, YOO HYUK SANG: "Michael-Type Addition of Gelatin on Electrospun Nanofibrils for Self-Assembly of Cell Sheets Composed of Human Dermal Fibroblasts", ACS OMEGA, ACS PUBLICATIONS, US, vol. 4, no. 20, 12 November 2019 (2019-11-12), US , pages 18677 - 18684, XP055950406, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b02602

LIM, Sang Yeob (KR)

View/Download PDF      PDF Help

Previous Patent: ZOOM DRIVE ACTUATOR

Next Patent: REFRIGERATOR