Title:
MODIFIED HUMAN PAPILLOMAVIRUS TYPE 52 L1 PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/111022
Kind Code:
A1
Abstract:
The present application relates to a modified human papillomavirus (HPV) type 52 L1 protein and a use thereof. Specifically, the present application relates to a HPV type 52 L1 protein, a nucleotide encoded thereby, a carrier comprising the nucleotide, a cell comprising the carrier, a pentamer or virus-like particle consisting of the HPV-52 L1 protein, a vaccine comprising the pentamer or virus-like particle and a vaccine adjuvant, and a use thereof in the prevention of HPV infections and HPV infection-related diseases.
Inventors:
XU XUEMEI (CN)
MA MINGRAO (CN)
HAO YARU (CN)
ZHANG TING (CN)
WANG ZHIRU (CN)
MA MINGRAO (CN)
HAO YARU (CN)
ZHANG TING (CN)
WANG ZHIRU (CN)
Application Number:
PCT/CN2021/120518
Publication Date:
June 02, 2022
Filing Date:
September 26, 2021
Export Citation:
Assignee:
INST BASIC MEDICAL SCIENCES CAMS (CN)
International Classes:
C07K14/025; A61K39/12; A61P31/20; C12N7/04; C12N15/37; C12N15/63; C12N15/866
Foreign References:
| CN1934131A | 2007-03-21 | |||
| CN101245099A | 2008-08-20 | |||
| CN1976718A | 2007-06-06 | |||
| CN102268076A | 2011-12-07 | |||
| US6361778B1 | 2002-03-26 | |||
| CN101481408A | 2009-07-15 |
Other References:
GODI ANNA, BISSETT SARA L., MASLOH SOLÈNE, FLEURY MAXIME, LI SHAOWEI, ZHAO QINJIAN, XIA NINGSHAO, COCUZZA CLEMENTINA E., BEDDOWS S: "Impact of naturally occurring variation in the human papillomavirus 52 capsid proteins on recognition by type-specific neutralising antibodies", JOURNAL OF GENERAL VIROLOGY, vol. 100, no. 2, 1 February 2019 (2019-02-01), pages 237 - 245, XP055933763, ISSN: 0022-1317, DOI: 10.1099/jgv.0.001213
WEI MINXI, WANG DANING, LI ZHIHAI, SONG SHUO, KONG XIANGLIN, MO XIAOBING, YANG YUROU, HE MAOZHOU, LI ZHONGYI, HUANG BO, LIN ZHIJIE: "N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro", EMERGING MICROBES & INFECTIONS, vol. 7, no. 1, 26 September 2018 (2018-09-26), pages 1 - 12, XP055776029, DOI: 10.1038/s41426-018-0158-2
WEI MINXI, WANG DANING, LI ZHIHAI, SONG SHUO, KONG XIANGLIN, MO XIAOBING, YANG YUROU, HE MAOZHOU, LI ZHONGYI, HUANG BO, LIN ZHIJIE: "N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro", EMERGING MICROBES & INFECTIONS, vol. 7, no. 1, 26 September 2018 (2018-09-26), pages 1 - 12, XP055776029, DOI: 10.1038/s41426-018-0158-2
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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