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Title:
MODIFIED IMMUNE CELLS AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2023/108107
Kind Code:
A3
Abstract:
The present invention features modified immune cells (e.g., T- or NK-cells) having increased resistance to hypoxia-adenosinergic immunosuppression. Methods for producing and using the same are also provided.

Inventors:
MURRAY RYAN (US)
SITKOVSKY MICHAIL (US)
HATFIELD STEPHEN (US)
Application Number:
PCT/US2022/081241
Publication Date:
August 17, 2023
Filing Date:
December 09, 2022
Export Citation:
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Assignee:
BEAM THERAPEUTICS INC (US)
International Classes:
C12N9/78; A61K35/17; A61P35/00; C12N5/10; C12N15/113; C12N5/078; C12N9/22
Domestic Patent References:
WO2021127594A12021-06-24
WO2021062227A22021-04-01
WO2021097521A92021-07-01
WO2020168300A12020-08-20
Attorney, Agent or Firm:
HUNTER-ENSOR, Melissa (US)
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