Title:
MODIFIED LOW MOLECULAR WEIGHT GLUTENIN WITH REDUCED RISK TO PATIENTS WITH CELIAK DISEASE
Document Type and Number:
WIPO Patent Application WO2004078982
Kind Code:
A3
Abstract:
The present invention relates to transgenic plants, such as wheat or maize, comprising plant cells having SEQ.ID.NO 1 and seeds derived from those plants. It also relates to the use of said seed for the preparation of a flour which in turn is used for the preparation of food and/or feed such as dough, batters, pastries, cookies, pasta, wafers, bread and/or confectionery. The thus obtained gliadin-free foodstuff is beneficial for feeding patients suffering from coeliac disease and/or other forms of gluten intolerance.
Inventors:
BECKER DIRK (DE)
GAHRTZ MANFRED (DE)
LORZ HORST (DE)
SCHRODER MAREN (DE)
GAHRTZ MANFRED (DE)
LORZ HORST (DE)
SCHRODER MAREN (DE)
Application Number:
PCT/EP2004/002079
Publication Date:
October 28, 2004
Filing Date:
March 02, 2004
Export Citation:
Assignee:
MONSANTO AGRAR DEUTSCHLAND GMB (DE)
BECKER DIRK (DE)
GAHRTZ MANFRED (DE)
LORZ HORST (DE)
SCHRODER MAREN (DE)
BECKER DIRK (DE)
GAHRTZ MANFRED (DE)
LORZ HORST (DE)
SCHRODER MAREN (DE)
International Classes:
A01H5/00; A21D2/26; A21D13/04; A23L1/305; A23L7/10; A23L7/109; C07K14/415; C12N15/82; (IPC1-7): C12N15/82; A01H5/00
Other References:
DATABASE EMBL [online] EBI; 1 March 2002 (2002-03-01), IKEDA T.M. ET AL.: "Low-molecular-weight glutenin subunit group 8 type IV.", XP002247533, Database accession no. Q8W3V4
DATABASE EMBL [online] EBI; 1 May 1997 (1997-05-01), "Low-molecular-weight glutenin storage protein.", XP002247534, Database accession no. P93790
SCHUPPAN DETLEF ET AL: "Gluten and the gut: Lessons for immune regulation.", SCIENCE (WASHINGTON D C), vol. 297, no. 5590, 2002, 27 September, 2002, pages 2218 - 2220, XP002247531, ISSN: 0036-8075
VADER L W ET AL: "Specificity of tissue transglutaminase explains cereal toxicity in celiac disease", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 195, no. 5, 4 March 2002 (2002-03-04), pages 643 - 649, XP002204499, ISSN: 0022-1007
VADER WILLEMIJN ET AL: "The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.", GASTROENTEROLOGY, vol. 122, no. 7, June 2002 (2002-06-01), June, 2002, pages 1729 - 1737, XP009013823, ISSN: 0016-5085
DATABASE EMBL [online] EBI; 1 May 1997 (1997-05-01), "Low-molecular-weight glutenin storage protein.", XP002247534, Database accession no. P93790
SCHUPPAN DETLEF ET AL: "Gluten and the gut: Lessons for immune regulation.", SCIENCE (WASHINGTON D C), vol. 297, no. 5590, 2002, 27 September, 2002, pages 2218 - 2220, XP002247531, ISSN: 0036-8075
VADER L W ET AL: "Specificity of tissue transglutaminase explains cereal toxicity in celiac disease", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 195, no. 5, 4 March 2002 (2002-03-04), pages 643 - 649, XP002204499, ISSN: 0022-1007
VADER WILLEMIJN ET AL: "The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.", GASTROENTEROLOGY, vol. 122, no. 7, June 2002 (2002-06-01), June, 2002, pages 1729 - 1737, XP009013823, ISSN: 0016-5085
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