Title:
MODIFIED NATURETIC COMPOUNDS, CONJUGATES, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004047871
Kind Code:
A3
Abstract:
Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms to of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
Inventors:
JAMES KENNETH D
RADHAKRISHNAN BALASINGAM
MALKAR NAVDEEP B
MILLER MARK A
EKWURIBE NNOCHIRI N
RADHAKRISHNAN BALASINGAM
MALKAR NAVDEEP B
MILLER MARK A
EKWURIBE NNOCHIRI N
Application Number:
PCT/US2003/037996
Publication Date:
March 17, 2005
Filing Date:
November 12, 2003
Export Citation:
Assignee:
NOBEX CORP (US)
International Classes:
A61K47/48; C07K14/58; C07K14/72; C08G65/329; (IPC1-7): A61K38/22; A61K47/48; C07K14/58; C07K14/72; C08G65/32; C08G65/329; C08G65/333
Domestic Patent References:
| WO2000078302A1 | 2000-12-28 | |||
| WO2002098446A1 | 2002-12-12 |
Foreign References:
| US5342940A | 1994-08-30 | |||
| US6162902A | 2000-12-19 | |||
| EP0295679A2 | 1988-12-21 |
Other References:
CHANG T K ET AL: "Subtiligase: a tool for semisynthesis of proteins.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 20 DEC 1994, vol. 91, no. 26, 20 December 1994 (1994-12-20), pages 12544 - 12548, XP002280083, ISSN: 0027-8424
CONDON, J. AM. OIL. CHEM. SOC., vol. 71, no. 7, 1994, pages 739 - 741, XP001181312
CONDON, J. AM. OIL. CHEM. SOC., vol. 71, no. 7, 1994, pages 739 - 741, XP001181312
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