Title:
MODIFIED PHOTORECEPTIVE CHLORIDE CHANNEL
Document Type and Number:
WIPO Patent Application WO/2021/193732
Kind Code:
A1
Abstract:
The present invention addresses the issue of providing a modified photoreceptive chloride channel that has a narrow wavelength sensitivity range, has both short τon and short τoff, and has excellent photoreactivity. The solution is a polypeptide in which a region from the fourth transmembrane domain to the sixth transmembrane domain, counted from an N terminal-side of a Guillardia theta-derived photoreceptive chloride channel-1 (GtACR1), is replaced by a region corresponding to a Guillardia theta-derived photoreceptive chloride channel-2 (GtACR2).
Inventors:
TOMITA HIROSHI (JP)
SUGANO ERIKO (JP)
SUGANO ERIKO (JP)
Application Number:
PCT/JP2021/012283
Publication Date:
September 30, 2021
Filing Date:
March 24, 2021
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION IWATE UNIV (JP)
International Classes:
C12N15/62; A61K35/76; A61K38/16; A61K48/00; A61P27/02; C07K19/00; C12N5/10; C12N15/63
Domestic Patent References:
| WO2009119782A1 | 2009-10-01 |
Foreign References:
| JP2018509909A | 2018-04-12 |
Other References:
WANG, H. ET AL.: "Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins from Chlamydomonas", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 9, 27 February 2009 (2009-02-27), pages 5685 - 5696, XP008151880, DOI: 10.1074/jbc.M807632200
WEN, L. ET AL.: "Opto-Current-Clamp Actuation of Cortical Neurons Using a Strategically Designed Channelrhodopsin", PLOS ONE, vol. 5, no. 9, 23 September 2010 (2010-09-23), pages 1 - 9, XP055861223
WEN, L. ET AL.: "Opto-Current-Clamp Actuation of Cortical Neurons Using a Strategically Designed Channelrhodopsin", PLOS ONE, vol. 5, no. 9, 23 September 2010 (2010-09-23), pages 1 - 9, XP055861223
Attorney, Agent or Firm:
TSUJITA Takashi (JP)
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