Title:
MODIFIED PROTEINS AND PROTEIN BINDERS AND DEGRADERS
Document Type and Number:
WIPO Patent Application WO/2024/056077
Kind Code:
A1
Abstract:
Provided herein are compounds, pharmaceutical compositions, and methods for binding or modulating a DDB1-and CUL4-associated factor 1 (DCAF1) protein. In some aspects, the compound induces proteasomal degradation of a target protein.
Inventors:
LIU JING (US)
PLEWE MICHAEL BRUNO (US)
HAN XIAORAN (CN)
NA JIM (US)
LEE MATTHEW RANDOLPH (US)
ZHANG CHENGWEI (CN)
YANG TING (CN)
QIN LIHUAI (CN)
ZHOU JING (CN)
PLEWE MICHAEL BRUNO (US)
HAN XIAORAN (CN)
NA JIM (US)
LEE MATTHEW RANDOLPH (US)
ZHANG CHENGWEI (CN)
YANG TING (CN)
QIN LIHUAI (CN)
ZHOU JING (CN)
Application Number:
PCT/CN2023/119126
Publication Date:
March 21, 2024
Filing Date:
September 15, 2023
Export Citation:
Assignee:
CULLGEN SHANGHAI INC (CN)
International Classes:
C07D403/14; A61K31/407; A61K31/4468; A61K31/497; A61K31/506; A61P35/00; C07D417/14
Domestic Patent References:
| WO2019201123A1 | 2019-10-24 | |||
| WO2009051822A1 | 2009-04-23 | |||
| WO2018106870A1 | 2018-06-14 |
Other References:
KIMANI SERAH W., OWEN JULIE, GREEN STUART R., LI FENGLING, LI YANJUN, DONG AIPING, BROWN PETER J., ACKLOO SUZANNE, KUTER DAVID, YA: "Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets", JOURNAL OF CHEMICAL INFORMATION AND MODELING, AMERICAN CHEMICAL SOCIETY , WASHINGTON DC, US, vol. 63, no. 13, 10 July 2023 (2023-07-10), US , pages 4070 - 4078, XP093147954, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.3c00082
DATABASE REGISTRY ANONYMOUS : "- Ethanone, 1-[4-[6-[[1-(3-fluorophenyl)-3-piperidinyl]amino]-4-pyrimidinyl]- 1-piperazinyl]- (CA INDEX NAME)", XP093147959, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-5-Pyrimidinecarbonitrile, 4-[[1-(3-fluorophenyl)-3-piperidinyl]amino]-6methyl-(CA INDEX NAME) ", XP093147961, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Ethanone, 1-[4-[6-[[1-(3-fluorophenyl)-3-piperidinyl]amino]-4-pyrimidinyl]- 1-piperazinyl]- (CA INDEX NAME)", XP093147959, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-5-Pyrimidinecarbonitrile, 4-[[1-(3-fluorophenyl)-3-piperidinyl]amino]-6methyl-(CA INDEX NAME) ", XP093147961, retrieved from STN
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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