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Title:
MODIFIED PROTEINS AND PROTEIN DEGRADERS
Document Type and Number:
WIPO Patent Application WO/2023/061440
Kind Code:
A1
Abstract:
Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are bifunctional compounds having a DNA damage-binding protein 1 (DDB1) binding moiety, a linker, and a target binding moiety.

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Inventors:
LIU JING (US)
PLEWE MICHAEL BRUNO (US)
HAN XIAORAN (CN)
ZHANG CHENGWEI (CN)
YANG TING (CN)
CHEN LIQUN (CN)
LEE MATTHEW RANDOLPH (US)
ZHOU JING (CN)
DING JIE (CN)
WANG JIALIANG (US)
Application Number:
PCT/CN2022/125080
Publication Date:
April 20, 2023
Filing Date:
October 13, 2022
Export Citation:
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Assignee:
CULLGEN SHANGHAI INC (CN)
International Classes:
C07D471/04; A61P35/00; C07D401/14; C07D409/14; C07D417/14; C07D487/04; C07D487/14; C07D495/14
Domestic Patent References:
WO2021239117A12021-12-02
WO2020173440A12020-09-03
WO2020207396A12020-10-15
WO2021065980A12021-04-08
WO2020092662A12020-05-07
WO2020219650A12020-10-29
Foreign References:
CN112409376A2021-02-26
CN112533918A2021-03-19
CN109071552A2018-12-21
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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