Title:
MODIFIED TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE POLYMERASES
Document Type and Number:
WIPO Patent Application WO/2023/240202
Kind Code:
A3
Abstract:
The present disclosure provides modified terminal deoxynucleotidyl (TdT) polymerases and compositions (e.g., conjugates) comprising modified TdT polymerases. The present disclosure also provides circularly permuted terminal deoxynucleotidyl (TdT) polymerases as well as modified TdT polymerases and compositions (e.g., conjugates) comprising such cpTdT or modified TdT polymerases. Also provided are nucleic acids, vectors, and host cells encoding modified TdT polymerases, as well as methods including methods of producing modified TdT polymerases, and methods of using modified TdT polymerases (e.g., methods of nucleic acid synthesis).
Inventors:
ELLEFSON JARED (US)
BARTHEL SEBASTIAN (US)
PALLUK SEBASTIAN (US)
ARLOW DANIEL (US)
ESTRIN ERIC (US)
BARTHEL SEBASTIAN (US)
PALLUK SEBASTIAN (US)
ARLOW DANIEL (US)
ESTRIN ERIC (US)
Application Number:
PCT/US2023/068148
Publication Date:
February 08, 2024
Filing Date:
June 08, 2023
Export Citation:
Assignee:
ANSA BIOTECHNOLOGIES INC (US)
International Classes:
C12N9/12; C07K19/00; C12N15/52; C12N15/62; C12P19/34
Domestic Patent References:
| WO2021257795A1 | 2021-12-23 |
Foreign References:
| US20190112627A1 | 2019-04-18 | |||
| US20200002690A1 | 2020-01-02 |
Attorney, Agent or Firm:
SMITH, Maria, C. et al. (US)
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