MODULAR ORGAN MICROPHYSIOLOGICAL SYSTEM WITH MICROBIOME

WIPO Patent Application WO/2018/175478

A3

Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks with microbiome for an extended period of time of at least weeks and months. The platform has one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self- leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs together with microbiome in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology- based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the bioreactors is also provided.

GRIFFITH LINDA (US)
TRUMPER DAVID (US)
EDINGTON COLLIN (US)
ROHATGI GAURAV (US)
FREAKE DUNCAN (US)
SOENKSEN LUIS (US)
KASSIS TIMOTHY (US)
BHUSHAN BRIJ (US)

PCT/US2018/023411

November 15, 2018

March 20, 2018

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MASSACHUSETTS INST TECHNOLOGY (US)

C12M1/00; B01L3/00; C12M1/12; C12M1/32; F04B19/00; F04B23/06; F04B43/04; G01F23/00

US20050260745A1	2005-11-24
US20100230613A1	2010-09-16

KAREL DOMANSKY ET AL: "Perfused multiwell plate for 3D liver tissue engineering", LAB ON A CHIP, vol. 10, no. 1, 1 January 2010 (2010-01-01), pages 51 - 58, XP055174411, ISSN: 1473-0197, DOI: 10.1039/B913221J

PABST, Patrea, L. et al. (US)

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