Title:
MODULATED OPTICAL TWEEZERS
Document Type and Number:
WIPO Patent Application WO2006078759
Kind Code:
A3
Abstract:
A method and apparatus for selecting a specific fraction from a heterogeneous fluid-borne sample using optical gradient forces in a microfluidic or fluidic system are presented. Samples may range in size from a few nanometers to at least tens of micrometers, may be dispersed in any fluid medium transported from input channels (410) to output channels (430), and may be sorted on the basis of size, shape, optical characteristics, charge, and other physical properties. The selection process involves passive transport through optical intensity field - an array of optical traps or optical tweezers driven by flowing fluid, and so offers several advantages over competing techniques. These include continuous rather than batch-mode operation, continuous and dynamic tunability, operation over a wide range of samples, compactness, and low cost.
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Inventors:
GRIER DAVID G (US)
Application Number:
PCT/US2006/001806
Publication Date:
December 21, 2006
Filing Date:
January 19, 2006
Export Citation:
Assignee:
UNIV NEW YORK (US)
GRIER DAVID G (US)
GRIER DAVID G (US)
International Classes:
G03H1/08; G21K1/00
Domestic Patent References:
| WO2004100175A1 | 2004-11-18 | |||
| WO2004012133A2 | 2004-02-05 | |||
| WO2001035150A1 | 2001-05-17 |
Foreign References:
| US20020132316A1 | 2002-09-19 | |||
| US20050001063A1 | 2005-01-06 |
Other References:
PELTON M, LADAVAC K, GRIER D G: "Transport and fractionation in periodic potential-energy landscapes", PHYSICAL REVIEW E, vol. 70, 24 September 2004 (2004-09-24), pages 031108-1 - 031108-10, XP002385228
MACDONALD ET AL: "MICROFLUIDIC SORTING IN AN OPTICAL LATTICE", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 426, 27 November 2003 (2003-11-27), pages 421 - 424, XP002289740, ISSN: 0028-0836
GUCK J, ANANTHAKRISHNAN R, CUNNINGHAM C C, KÄS J: "Stretching biological cells with light", JOURNAL OF PHYSICS: CONDENSED MATTER, vol. 14, 2 May 2002 (2002-05-02), pages 4843 - 4856, XP002385229
SINCLAIR G ET AL: "Assembly of 3-dimensional structures using programmable holographic optical tweezers", OPTICS EXPRESS OPT. SOC. AMERICA USA, vol. 12, no. 22, 1 November 2004 (2004-11-01), pages 5475 - 5480, XP002397633, ISSN: 1094-4087
BOUTENKO V ET AL: "Second order direct binary search algorithm for the synthesis of computer-generated holograms", OPTICS COMMUNICATIONS, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 125, no. 1, 1 April 1996 (1996-04-01), pages 43 - 47, XP004009975, ISSN: 0030-4018
REICHERTER M ET AL: "OPTICAL PARTICLE TRAPPING WITH COMPUTER-GENERATED HOLOGRAMS WRITTEN ON A LIQUID-CRYSTAL DISPLAY", OPTICS LETTERS, OSA, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC, US, vol. 24, no. 9, 1 May 1999 (1999-05-01), pages 608 - 610, XP000830382, ISSN: 0146-9592
MACDONALD ET AL: "MICROFLUIDIC SORTING IN AN OPTICAL LATTICE", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 426, 27 November 2003 (2003-11-27), pages 421 - 424, XP002289740, ISSN: 0028-0836
GUCK J, ANANTHAKRISHNAN R, CUNNINGHAM C C, KÄS J: "Stretching biological cells with light", JOURNAL OF PHYSICS: CONDENSED MATTER, vol. 14, 2 May 2002 (2002-05-02), pages 4843 - 4856, XP002385229
SINCLAIR G ET AL: "Assembly of 3-dimensional structures using programmable holographic optical tweezers", OPTICS EXPRESS OPT. SOC. AMERICA USA, vol. 12, no. 22, 1 November 2004 (2004-11-01), pages 5475 - 5480, XP002397633, ISSN: 1094-4087
BOUTENKO V ET AL: "Second order direct binary search algorithm for the synthesis of computer-generated holograms", OPTICS COMMUNICATIONS, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 125, no. 1, 1 April 1996 (1996-04-01), pages 43 - 47, XP004009975, ISSN: 0030-4018
REICHERTER M ET AL: "OPTICAL PARTICLE TRAPPING WITH COMPUTER-GENERATED HOLOGRAMS WRITTEN ON A LIQUID-CRYSTAL DISPLAY", OPTICS LETTERS, OSA, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC, US, vol. 24, no. 9, 1 May 1999 (1999-05-01), pages 608 - 610, XP000830382, ISSN: 0146-9592
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