Title:
MODULATION OF IAMT (PIMT OR PCMT) IN IMMUNE SYSTEM
Document Type and Number:
WIPO Patent Application WO2003057204
Kind Code:
A3
Abstract:
Modulation of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase activity in immune system associated cells enables the prevention or alleviation of an autoimmune response by decreasing self-antigen presentation or T-cell proliferation.
More Like This:
Inventors:
CLOOS PAUL ANDREAS COMPARE (DK)
Application Number:
PCT/EP2003/000079
Publication Date:
February 05, 2004
Filing Date:
January 07, 2003
Export Citation:
Assignee:
NORDIC BIOSCIENCE AS (DK)
CLOOS PAUL ANDREAS COMPARE (DK)
CLOOS PAUL ANDREAS COMPARE (DK)
International Classes:
C07D313/14; C12N9/10; C12Q1/68; (IPC1-7): C07D313/14; A61K31/335; C07D337/14; C07D405/06; C12N9/00; C12N15/54; C12Q1/48; C12Q1/68; G01N33/573
Domestic Patent References:
| WO1997045422A1 | 1997-12-04 | |||
| WO1998015647A1 | 1998-04-16 | |||
| WO2001083719A2 | 2001-11-08 | |||
| WO2002052016A2 | 2002-07-04 | |||
| WO2002008395A2 | 2002-01-31 |
Foreign References:
| EP0726265A1 | 1996-08-14 | |||
| US5780500A | 1998-07-14 | |||
| GB1080979A | 1967-08-31 | |||
| US3641056A | 1972-02-08 | |||
| US3100207A | 1963-08-06 | |||
| GB1098347A | 1968-01-10 |
Other References:
PERNA A F ET AL: "Metabolic consequences of Hyperhomocysteinemia in uremia.", AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 38, no. 4 suppl 1, October 2001 (2001-10-01), pages s85 - s90, XP002902941, ISSN: 0272-6386
ZIMMERMANN K ET AL: "Dibenzoxepines as treatments for neurodegenerative diseases.", PURE APPL. CHEM., vol. 71, no. 11, 1999, pages 2039 - 2046, XP002902886
DOROTEA MÜCK-SELER ET AL: "TCH-346 novartis.", I DRUGS, vol. 3, no. 5, 2000, pages 530 - 535, XP002902887, ISSN: 1369-7056
TSAI W ET AL: "Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 203, no. 1, 30 August 1994 (1994-08-30), pages 491 - 497, XP002902942, ISSN: 0006-291x
HUEBSCHER K J ET AL: "Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis.", GENE, vol. 240, 1999, pages 333 - 341, XP002902939, ISSN: 0378-1119
XIAODONG CHENG ET AL: "Adomet- dependent methylation, DNA methyltransferases and base flipping.", NUCLEIC ACIDS RESEARCH SURVEY AND SUMMARY, vol. 29, no. 18, 2001, XP002902940
ZIMMERMANN K ET AL: "Dibenzoxepines as treatments for neurodegenerative diseases.", PURE APPL. CHEM., vol. 71, no. 11, 1999, pages 2039 - 2046, XP002902886
DOROTEA MÜCK-SELER ET AL: "TCH-346 novartis.", I DRUGS, vol. 3, no. 5, 2000, pages 530 - 535, XP002902887, ISSN: 1369-7056
TSAI W ET AL: "Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 203, no. 1, 30 August 1994 (1994-08-30), pages 491 - 497, XP002902942, ISSN: 0006-291x
HUEBSCHER K J ET AL: "Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis.", GENE, vol. 240, 1999, pages 333 - 341, XP002902939, ISSN: 0378-1119
XIAODONG CHENG ET AL: "Adomet- dependent methylation, DNA methyltransferases and base flipping.", NUCLEIC ACIDS RESEARCH SURVEY AND SUMMARY, vol. 29, no. 18, 2001, XP002902940
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