Title:
MODULATION OF INTERACTIONS BETWEEN MYOSIN AND INTEGRINS
Document Type and Number:
WIPO Patent Application WO1998022500
Kind Code:
A3
Abstract:
The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the beta -subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.
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Inventors:
JENKINS ALISON L
PHILLIPS DAVID R
PHILLIPS DAVID R
Application Number:
PCT/US1997/022422
Publication Date:
October 15, 1998
Filing Date:
November 21, 1997
Export Citation:
Assignee:
COR THERAPEUTICS INC (US)
International Classes:
A61K45/00; A61K38/00; A61P7/02; A61P9/00; A61P21/02; A61P29/00; A61P35/00; C07K14/705; C07K14/78; (IPC1-7): C07K14/405; A61K38/39; C07K14/78
Domestic Patent References:
| WO1997014432A1 | 1997-04-24 | |||
| WO1995034641A1 | 1995-12-21 | |||
| WO1995025173A1 | 1995-09-21 |
Foreign References:
| US5498649A | 1996-03-12 |
Other References:
LAW DA ET AL: "Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine *phosphorylation* induced by platelet aggregation.", J BIOL CHEM, MAY 3 1996, 271 (18) P10811-5, UNITED STATES, XP002062627
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