Title:
MODULATORS OF CERAMIDASE AND METHODS OF USE BASED THEREON
Document Type and Number:
WIPO Patent Application WO2003005965
Kind Code:
A3
Abstract:
The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as methods screening for compounds that inhibit mitochondrial ceramidase. The invention also relates to the use of the compounds as a regulator of the level of ceramide by inhibiting ceramidase activity. The invention also relates to methods for the prevention and treatment of diseases associated with cell overproliferation and sphingolipid signal transduction including cancer, cardiovascular diseases, and inflammation.
Inventors:
BIELAWSKA ALICJA (US)
HANNUN YUSUF A (US)
SZULC ZDZISLAW (US)
USTA JULNAR (US)
EL BAWAB SAMER (US)
HANNUN YUSUF A (US)
SZULC ZDZISLAW (US)
USTA JULNAR (US)
EL BAWAB SAMER (US)
Application Number:
PCT/US2002/022151
Publication Date:
May 15, 2003
Filing Date:
July 11, 2002
Export Citation:
Assignee:
MUSC FOUND FOR RES DEV (US)
BIELAWSKA ALICJA (US)
HANNUN YUSUF A (US)
SZULC ZDZISLAW (US)
USTA JULNAR (US)
EL BAWAB SAMER (US)
BIELAWSKA ALICJA (US)
HANNUN YUSUF A (US)
SZULC ZDZISLAW (US)
USTA JULNAR (US)
EL BAWAB SAMER (US)
International Classes:
A61P9/00; A61P29/00; A61P35/00; C07C215/24; C07C217/46; C07C233/18; C07C275/20; C07F9/113; (IPC1-7): C07C275/04; C07C275/06; C07C275/10; C07C275/12; C07C275/20; C07C275/22
Foreign References:
| US4272413A | 1981-06-09 | |||
| US5902899A | 1999-05-11 |
Other References:
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS (COLUMBUS, OHIO, USA); "Preparation of ceramide -type compounds for application in cosmetic formulations", XP002960825, accession no. STN Database accession no. 1999:401043
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS (COLUMBUS, OHIO, USA); "Preparation of spisulosine derivatives for therapeutic use as antitumor agents", XP002960826, accession no. STN Database accession no. 2001:904189
USTA ET AL.: "Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase", BIOCHEMISTRY, vol. 40, 21 July 2001 (2001-07-21), pages 9657 - 9668, XP002960895
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS (COLUMBUS, OHIO, USA); "Preparation of spisulosine derivatives for therapeutic use as antitumor agents", XP002960826, accession no. STN Database accession no. 2001:904189
USTA ET AL.: "Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase", BIOCHEMISTRY, vol. 40, 21 July 2001 (2001-07-21), pages 9657 - 9668, XP002960895
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