Title:
Modulators of ovarial apoptosis related to IAP
Document Type and Number:
WIPO Patent Application WO1998022131
Kind Code:
A3
Inventors:
TSANG BENJAMIN K (CA)
KORNELUK ROBERT G (CA)
KORNELUK ROBERT G (CA)
Application Number:
PCT/IB1997/001506
Publication Date:
July 30, 1998
Filing Date:
November 14, 1997
Export Citation:
Assignee:
TSANG BENJAMIN K (CA)
KORNELUK ROBERT G (CA)
UNIV OTTAWA (CA)
KORNELUK ROBERT G (CA)
UNIV OTTAWA (CA)
International Classes:
A61K38/17; A61K38/48; C07K16/18; A61K38/00; (IPC1-7): G01N33/50; A61K31/70; A61K38/17; A61K38/24; A61K38/48; A61K38/55
Domestic Patent References:
| WO1988005662A1 | 1988-08-11 | |||
| WO1996035703A1 | 1996-11-14 |
Other References:
LISTON P ET AL: "SUPPRESSION OF APOPTOSIS IN MAMMALIAN CELLS BY NAIP AND A RELATED FAMILY OF IAP GENES", NATURE, vol. 379, no. 6563, 25 January 1996 (1996-01-25), pages 349 - 353, XP002032296
TILLY ET AL.: "Expression of members of the Bcl-2 gene family in the immature rat ovary: Equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels", ENDOCRINOLOGY, vol. 136, no. 1, 1995, pages 232 - 241, XP002056443
LAFON ET AL.: "Transforming growth factor beta-1-induced apoptosis in the human ovarion carcinoma cells: protection by the antioxidant N-acetylcysteine and Bcl-2", CELL GROWTH DIFFERENTIATION, vol. 7, no. 8, August 1996 (1996-08-01), pages 1095 - 1104, XP002056444
AMSTERDAM A ET AL: "Cross-talk between cAMP and p53-generated signals in induction of differentiation and apoptosis in steroidogenic granulosa cells", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 61, no. 4, April 1996 (1996-04-01), pages 252-256, XP004026584
TILLY ET AL.: "Expression of members of the Bcl-2 gene family in the immature rat ovary: Equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels", ENDOCRINOLOGY, vol. 136, no. 1, 1995, pages 232 - 241, XP002056443
LAFON ET AL.: "Transforming growth factor beta-1-induced apoptosis in the human ovarion carcinoma cells: protection by the antioxidant N-acetylcysteine and Bcl-2", CELL GROWTH DIFFERENTIATION, vol. 7, no. 8, August 1996 (1996-08-01), pages 1095 - 1104, XP002056444
AMSTERDAM A ET AL: "Cross-talk between cAMP and p53-generated signals in induction of differentiation and apoptosis in steroidogenic granulosa cells", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 61, no. 4, April 1996 (1996-04-01), pages 252-256, XP004026584
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