Title:
MOLECULAR MARKER FOR DETERMINING VERY-EARLY-STAGE ONSET RISK OF GASTRIC CANCER AND EVALUATING PROGRESSION RISK OF PRE-CANCEROUS LESION OF GASTRIC CANCER, AND USE THEREOF IN DIAGNOSTIC KIT
Document Type and Number:
WIPO Patent Application WO/2023/065609
Kind Code:
A1
Abstract:
Monoclonal antibodies of molecular markers (KRT7, KLK10 and LAMC2) for specifically marking very-early-stage cells of gastric cancer are prepared, and are used in the preparation of a kit for determining the very-early-stage onset risk of gastric cancer or other digestive tract tumors on the basis of gastric tissue or blood. The results show that: 1) the overall accuracy rate of predicting the progression risk of low-grade dysplasia reaches 86%, and the AUC value reaches 0.87; 2) the accuracy rate is closely related to the progression time of low-grade dysplasia, wherein the accuracy rate is increased to 95% 6 months before the onset of gastric cancer, and the window for the early diagnosis of gastric cancer can be moved forward by an average of 10 months; and 3) the accuracy rate of the marker in diagnosing gastric cancer is over 97%. The markers can also be used for distinguishing the postoperative recurrence risk of gastric cancer.
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Inventors:
LI SHAO (CN)
ZHANG PENG (CN)
ZHANG PENG (CN)
Application Number:
PCT/CN2022/085212
Publication Date:
April 27, 2023
Filing Date:
April 04, 2022
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
LI SHAO (CN)
ZHANG PENG (CN)
LI SHAO (CN)
ZHANG PENG (CN)
International Classes:
G01N33/574; G01N33/577
Foreign References:
| CN113970638A | 2022-01-25 | |||
| CN111781356A | 2020-10-16 | |||
| CN106868102A | 2017-06-20 |
Other References:
LIU JING, MA LIANG, CHEN ZHIMING, SONG YAO, GU TINGING, LIU XIANCHEN, ZHAO HONGYU, YAO NINGHUA: "Identification of critical genes in gastric cancer to predict prognosis using bioinformatics analysis methods", ANNALS OF TRANSLATIONAL MEDICINE, vol. 8, no. 14, 1 July 2020 (2020-07-01), US , pages 884 - 884, XP093057879, ISSN: 2305-5839, DOI: 10.21037/atm-20-4427
SUNG GI-HO, CHANG HYUN, LEE JI-YONG, SONG SI YOUNG, KIM HAN-SOO: "Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro", ANIMAL CELLS AND SYSTEMS, KOREAN ASSOCIATION OF BIOLOGICAL SCIENCES, vol. 22, no. 6, 2 November 2018 (2018-11-02), pages 368 - 381, XP093057880, ISSN: 1976-8354, DOI: 10.1080/19768354.2018.1527721
FRANCISCO J. OSSANDON ET AL.: "In Silico Analysis of Gastric Carcinoma Serial Analysis of Gene Expression Libraries Reveals Different Profiles Associated with Ethnicity", MOLECULAR CANCER, vol. 7, 27 February 2008 (2008-02-27), XP021036942, ISSN: 1476-4598
SUNG GI-HO, CHANG HYUN, LEE JI-YONG, SONG SI YOUNG, KIM HAN-SOO: "Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro", ANIMAL CELLS AND SYSTEMS, KOREAN ASSOCIATION OF BIOLOGICAL SCIENCES, vol. 22, no. 6, 2 November 2018 (2018-11-02), pages 368 - 381, XP093057880, ISSN: 1976-8354, DOI: 10.1080/19768354.2018.1527721
FRANCISCO J. OSSANDON ET AL.: "In Silico Analysis of Gastric Carcinoma Serial Analysis of Gene Expression Libraries Reveals Different Profiles Associated with Ethnicity", MOLECULAR CANCER, vol. 7, 27 February 2008 (2008-02-27), XP021036942, ISSN: 1476-4598
Attorney, Agent or Firm:
JINHENG LAW FIRM (CN)
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