Title:
MONO- AND POLYCYCLIC COMPOUNDS WITH THERAPEUTIC ACTIVITY, PHARMACEUTICAL COMPOSITIONS INCLUDING THEM AND INTERMEDIATES FOR MAKING THEM
Document Type and Number:
WIPO Patent Application WO2006005142
Kind Code:
A3
Abstract:
This invention provides novel biologically active monocyclic and polycyclic compounds, in particular bicyclic compounds, having some degree of structural similarity with the simmondsin scaffold, as well as monocyclic intermediates for making them. The invention also provides methods for making the novel active compounds from said intermediates, pharmaceutical compositions comprising them optionally in combination with an anti-angiogenic agent, and methods of treatment or prevention of angiogenesis-related diseases.
Inventors:
VAN DER EYCKEN JOHAN (BE)
Application Number:
PCT/BE2005/000114
Publication Date:
August 24, 2006
Filing Date:
July 13, 2005
Export Citation:
Assignee:
UNIV GENT (BE)
VAN DER EYCKEN JOHAN (BE)
VAN DER EYCKEN JOHAN (BE)
International Classes:
C07H15/207; A61K31/7034; A61P35/00; C07H15/26
Domestic Patent References:
| WO2004004746A1 | 2004-01-15 | |||
| WO2003063828A1 | 2003-08-07 |
Foreign References:
| NL8901639A | 1991-01-02 |
Other References:
N. CHIDA ET AL.: "Synthesis and absolute configuration of the naturally occurring cyano glucoside simmondsin", J. CHEM. SOC. PERKIN TRANS. 1, 1992, pages 1131 - 1137, XP002317457
R. E. HARRY-O'KURU: "Modification of simmondsin and its demethylated analogues", INDUSTRIAL CROPS AND PRODUCTS, vol. 12, 2000, pages 215 - 221, XP002317458
MAGNUS P ET AL: "Direct conversion of alpha,beta-unsaturated nitriles into cyanohydrins using Mn(dpm)3 catalyst, dioxygen and phenylsilane", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 25, 18 June 2001 (2001-06-18), pages 4127 - 4129, XP004241479, ISSN: 0040-4039
BOVEN VAN M ET AL: "ISOLATION AND STRUCTURE ELUCIDATION OF THE MAJOR SIMMONDSIN ANALOGUES IN JOJOBA MEAL BY TWO-DIMENSIONAL NMR SPECTROSCOPY", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 12, December 1994 (1994-12-01), pages 2684 - 2687, XP002921710, ISSN: 0021-8561
S. DAMTOFT, R. JENSEN: "Cyclohexyl butenolide glucosides from Epacridaceae", PHYTOCHEMISTRY, vol. 40, 1995, pages 157 - 159, XP002368218
L.R. SIMPOL: "Nitrile glucosides and rosmarinic acid, the histamine inhibitor from Ehretia Philippinensis", PHYTOCHEMISTRY, vol. 36, 1994, pages 91 - 95, XP002368219
M. VAN BOVEN ET AL.: "Isolation and structural identification of a new simmondsin ferulate from Jojoba Meal", J. AGRIC. FOOD CHEM., vol. 42, 1994, pages 1118 - 1121, XP002368220
M. VAN BOVEN ET AL.: "New Simmondsin 2'-ferulates from Jojoba meal", J. AGRIC. FOOD CHEM., vol. 43, 1995, pages 1193 - 1197, XP002368221
R. E. HARRY-O'KURU: "Modification of simmondsin and its demethylated analogues", INDUSTRIAL CROPS AND PRODUCTS, vol. 12, 2000, pages 215 - 221, XP002317458
MAGNUS P ET AL: "Direct conversion of alpha,beta-unsaturated nitriles into cyanohydrins using Mn(dpm)3 catalyst, dioxygen and phenylsilane", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 25, 18 June 2001 (2001-06-18), pages 4127 - 4129, XP004241479, ISSN: 0040-4039
BOVEN VAN M ET AL: "ISOLATION AND STRUCTURE ELUCIDATION OF THE MAJOR SIMMONDSIN ANALOGUES IN JOJOBA MEAL BY TWO-DIMENSIONAL NMR SPECTROSCOPY", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 12, December 1994 (1994-12-01), pages 2684 - 2687, XP002921710, ISSN: 0021-8561
S. DAMTOFT, R. JENSEN: "Cyclohexyl butenolide glucosides from Epacridaceae", PHYTOCHEMISTRY, vol. 40, 1995, pages 157 - 159, XP002368218
L.R. SIMPOL: "Nitrile glucosides and rosmarinic acid, the histamine inhibitor from Ehretia Philippinensis", PHYTOCHEMISTRY, vol. 36, 1994, pages 91 - 95, XP002368219
M. VAN BOVEN ET AL.: "Isolation and structural identification of a new simmondsin ferulate from Jojoba Meal", J. AGRIC. FOOD CHEM., vol. 42, 1994, pages 1118 - 1121, XP002368220
M. VAN BOVEN ET AL.: "New Simmondsin 2'-ferulates from Jojoba meal", J. AGRIC. FOOD CHEM., vol. 43, 1995, pages 1193 - 1197, XP002368221
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