MONOCLONAL ANTIBODIES THAT INHIBIT THE WNT SIGNALING PATHWAY AND METHODS OF PRODUCTION AND USE THEREOF

Title:

MONOCLONAL ANTIBODIES THAT INHIBIT THE WNT SIGNALING PATHWAY AND METHODS OF PRODUCTION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2011/103426

Kind Code:

A3

Abstract:

Monoclonal antibodies against LRP6 and that block the Wnt signaling pathway are disclosed. Methods of production and use thereof are also disclosed.

Inventors:

MA JIAN-XING (US)
LEE KYUNGWON (US)
CHEN YING (US)

Application Number:

PCT/US2011/025436

Publication Date:

January 19, 2012

Filing Date:

February 18, 2011

Export Citation:

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Assignee:

UNIV OKLAHOMA (US)
MA JIAN-XING (US)
LEE KYUNGWON (US)
CHEN YING (US)

International Classes:

C07K16/18; A61K39/395; C12N15/13

Domestic Patent References:

WO2006089114A2	2006-08-24
WO2002092015A2	2002-11-21

Other References:

BINNERTS, M. E. ET AL.: "The first propeller domain of LRP6 regulates sensitivity to DKK1.", MOLECULAR BIOLOGY, vol. 20, 28 May 2009 (2009-05-28), pages 3552 - 3560, XP002646369
YOUNG, J. J. ET AL.: "LRP5 and LRP6 are not required for protective antigen- mediated internalization or lethality of anthrax lethal toxin.", PLOS PATHOGENS, vol. 3, no. 3, 2 March 2007 (2007-03-02), pages E27, XP002465399
HASSLER, C. ET AL.: "Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.", DEVELOPMENT, vol. 134, 31 October 2007 (2007-10-31), pages 4255 - 4263, XP008167280
See also references of EP 2536761A4

Attorney, Agent or Firm:

HESTER, Kathryn, L. (P. C.P.O. Box 1637, Oklahoma City OK, US)

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