Title:
MONOCLONAL ANTIBODY AGAINST HUMAN TAU PROTEIN
Document Type and Number:
WIPO Patent Application WO/2016/041553
Kind Code:
A3
Abstract:
The invention relates to the monoclonal antibody 1G2, the hybridoma cell line H-1 G2 characterized by DSM ACC3248, and the epitope TPP comprising the amino acids tryptophan, proline, proline. The invention further relates to a method for producing a monoclonal antibody against a TAU protein fraction that is non-phosphorylated in positions T175 and/or T181 and/or T231. The invention also describes uses of the monoclonal antibody 1 G2 as well as an immunochemical detection system and the uses thereof. The invention finally describes the use of the immunochemical detection system for diagnosing Alzheimer's disease in humans.
Inventors:
LACHMANN INGOLF (DE)
HOLZER MAX (DE)
LEWCZUK PIOTR (DE)
KORNHUBER JOHANNES (DE)
PERRET-LIAUDET ARMAND (FR)
FLACH KATHARINA (DE)
HOLZER MAX (DE)
LEWCZUK PIOTR (DE)
KORNHUBER JOHANNES (DE)
PERRET-LIAUDET ARMAND (FR)
FLACH KATHARINA (DE)
Application Number:
PCT/DE2015/100394
Publication Date:
December 15, 2016
Filing Date:
September 17, 2015
Export Citation:
Assignee:
AJ ROBOSCREEN GMBH (DE)
International Classes:
C07K16/18; G01N33/53
Domestic Patent References:
| WO2014100600A2 | 2014-06-26 | |||
| WO1995005466A1 | 1995-02-23 |
Foreign References:
| US20120295852A1 | 2012-11-22 |
Other References:
L. I. BINDER ET AL: "The distribution of tau in the mammalian central nervous system", THE JOURNAL OF CELL BIOLOGY, vol. 101, no. 4, 1 October 1985 (1985-10-01), pages 1371 - 1378, XP055161258, ISSN: 0021-9525, DOI: 10.1083/jcb.101.4.1371
N GHOSHAL: "Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease", EXPERIMENTAL NEUROLOGY, vol. 177, no. 2, 1 October 2002 (2002-10-01), pages 475 - 493, XP055089574, ISSN: 0014-4886, DOI: 10.1006/exnr.2002.8014
N GHOSHAL: "Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease", EXPERIMENTAL NEUROLOGY, vol. 177, no. 2, 1 October 2002 (2002-10-01), pages 475 - 493, XP055089574, ISSN: 0014-4886, DOI: 10.1006/exnr.2002.8014
Attorney, Agent or Firm:
RECHTSANWALTSGESELLSCHAFT MBH DR. JUR. PETER NENNING (Petersstraße 39-41, Leipzig, DE)
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