Title:
MONOCLONAL ANTIBODY IMAGING AND THERAPY OF TUMORS THAT EXPRESS MET AND BIND HEPATOCYTE GROWTH FACTOR
Document Type and Number:
WIPO Patent Application WO2003057155
Kind Code:
A3
Abstract:
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met and its agonist ligand HGF. Disclosed herein are (a) mAbs and hybridoma cell lines that produce them, which mAbs antibodies are specific for Met and (b) combinations of anti-Met and anti-HGF mAbs. When detectably labeled, these antibodies are useful for imaging such tumors. Anti-Met mAb compositions and methods for scintigraphic detection, diagnosis, prognosis, monitoring and therapy of Met-bearing tumors are provided.
Inventors:
HAY RICK V (US)
CAO BOLIANG (US)
RESAU JAMES H (US)
VANDE WOUDE GEORGE F (US)
GROSS MILTON D (US)
CAO BOLIANG (US)
RESAU JAMES H (US)
VANDE WOUDE GEORGE F (US)
GROSS MILTON D (US)
Application Number:
PCT/US2002/041607
Publication Date:
January 20, 2005
Filing Date:
December 27, 2002
Export Citation:
Assignee:
VAN ANDEL RES INST (US)
US DEPT VETERANS AFFAIRS (US)
HAY RICK V (US)
CAO BOLIANG (US)
RESAU JAMES H (US)
VANDE WOUDE GEORGE F (US)
GROSS MILTON D (US)
US DEPT VETERANS AFFAIRS (US)
HAY RICK V (US)
CAO BOLIANG (US)
RESAU JAMES H (US)
VANDE WOUDE GEORGE F (US)
GROSS MILTON D (US)
International Classes:
G01N33/53; A61K9/08; A61K9/10; A61K39/395; A61K47/48; A61K49/00; A61K51/00; A61K51/10; A61P35/00; C07K16/28; C07K16/32; C07K16/40; C12N5/10; C12P21/08; G01N33/531; G01N33/574; G01N33/58; G01N33/60; (IPC1-7): G01N33/53; C07K16/00
Other References:
YAMADA ET AL.: "Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (cMet) in human brain tissues", BRAIN RES., vol. 637, 1994, pages 308 - 312, XP000863216
PRAT ET AL.: "C-terminal truncated forms of Met, the hepatocyte growth factor receptor", MOL. CELL. BIOL., vol. 11, no. 12, December 1991 (1991-12-01), pages 5954 - 5962, XP002903959
See also references of EP 1516185A4
PRAT ET AL.: "C-terminal truncated forms of Met, the hepatocyte growth factor receptor", MOL. CELL. BIOL., vol. 11, no. 12, December 1991 (1991-12-01), pages 5954 - 5962, XP002903959
See also references of EP 1516185A4
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