Title:
MONOCLONAL ANTIBODY FOR NOVEL CORONAVIRUS, OR ANTIGEN BINDING PART THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/227138
Kind Code:
A1
Abstract:
A monoclonal antibody for a novel coronavirus, or an antigen binding part thereof. The monoclonal antibody specifically binds to an S protein of the novel coronavirus. The monoclonal antibody contains a heavy chain variable region comprising amino acid sequences as shown in SEQ ID NO.1-3, SEQ ID NO.9-11, and SEQ ID NO.17-19, and a light chain variable region comprising amino acid sequences as shown in SEQ ID NO.5-7, SEQ ID NO.13-15, and SEQ ID NO.21-23. The monoclonal antibody can be used for detecting the existence of the novel coronavirus. In addition, the monoclonal antibody has neutralizing activity, and therefore can be used for the development of drugs for preventing or treating novel coronavirus infection.
Inventors:
ZHU FENGCAI (CN)
ZHANG LI (CN)
PAN HONGXING (CN)
GUO XILING (CN)
ZHANG LI (CN)
PAN HONGXING (CN)
GUO XILING (CN)
Application Number:
PCT/CN2020/092957
Publication Date:
November 18, 2021
Filing Date:
May 28, 2020
Export Citation:
Assignee:
JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION PUBLIC HEALTH RES INSTITUTE OF JIANGSU (CN)
International Classes:
C07K16/10; C07K14/165; C12N15/50; C12N15/70
Foreign References:
| CN110423278A | 2019-11-08 | |||
| CN1081716A | 1994-02-09 |
Other References:
CHUNYAN WANG, LI WENTAO, DRABEK DUBRAVKA, OKBA NISREEN M. A., VAN HAPEREN RIEN, OSTERHAUS ALBERT D. M. E., VAN KUPPEVELD FRANK J. : "A human monoclonal antibody blocking SARS-CoV-2 infection", NATURE COMMUNICATIONS, vol. 11, no. 1, XP055737066, DOI: 10.1038/s41467-020-16256-y
AHSAN WAQUAR, JAVED SHAMAMA, BRATTY MOHAMMED AL, ALHAZMI HASSAN A., NAJMI ASIM: "Treatment of SARS-CoV-2: How far have we reached?", DD&T DRUG DISCOVERIES & THERAPEUTICS, INTERNATIONAL ADVANCEMENT CENTER FOR MEDICINE & HEALTH RESEARCH CO., LTD., JAPAN, vol. 14, no. 2, 30 April 2020 (2020-04-30), Japan , pages 67 - 72, XP055866488, ISSN: 1881-7831, DOI: 10.5582/ddt.2020.03008
BALAMURUGAN SHANMUGARAJ, KONLAVAT SIRIWATTANANON, KITTIKHUN WANGKANONT, WARANYOO PHOOLCHAROEN: "Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)", ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, pages 10 - 18, XP055737131, Retrieved from the Internet [retrieved on 20201006], DOI: 10.12932/AP-200220-0773
ASHLEY BARLOW, LANDOLF KAITLIN M., BARLOW BROOKE, YEUNG SIU YAN AMY, HEAVNER JASON J., CLAASSEN CASSIDY W., HEAVNER MOJDEH S.: "Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019", PHARMACOTHERAPY, WILEY-BLACKWELL, US, vol. 40, no. 5, 7 April 2020 (2020-04-07), US , pages 416 - 437, XP055758182, ISSN: 0277-0008, DOI: 10.1002/phar.2398
MIGUEL ANGEL MARTINEZ: "Compounds with therapeutic potential against novel respiratory 2019 coronavirus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, UNITED STATES, United States , XP055729045, Retrieved from the Internet [retrieved on 20200909], DOI: 10.1128/aac.00399-20
AHSAN WAQUAR, JAVED SHAMAMA, BRATTY MOHAMMED AL, ALHAZMI HASSAN A., NAJMI ASIM: "Treatment of SARS-CoV-2: How far have we reached?", DD&T DRUG DISCOVERIES & THERAPEUTICS, INTERNATIONAL ADVANCEMENT CENTER FOR MEDICINE & HEALTH RESEARCH CO., LTD., JAPAN, vol. 14, no. 2, 30 April 2020 (2020-04-30), Japan , pages 67 - 72, XP055866488, ISSN: 1881-7831, DOI: 10.5582/ddt.2020.03008
BALAMURUGAN SHANMUGARAJ, KONLAVAT SIRIWATTANANON, KITTIKHUN WANGKANONT, WARANYOO PHOOLCHAROEN: "Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)", ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, pages 10 - 18, XP055737131, Retrieved from the Internet
ASHLEY BARLOW, LANDOLF KAITLIN M., BARLOW BROOKE, YEUNG SIU YAN AMY, HEAVNER JASON J., CLAASSEN CASSIDY W., HEAVNER MOJDEH S.: "Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019", PHARMACOTHERAPY, WILEY-BLACKWELL, US, vol. 40, no. 5, 7 April 2020 (2020-04-07), US , pages 416 - 437, XP055758182, ISSN: 0277-0008, DOI: 10.1002/phar.2398
MIGUEL ANGEL MARTINEZ: "Compounds with therapeutic potential against novel respiratory 2019 coronavirus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, UNITED STATES, United States , XP055729045, Retrieved from the Internet
Attorney, Agent or Firm:
BEIJING PREINTELL IP CO., LTD (CN)
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