Title:
MONOCLONAL ANTIBODY TARGETING TIGIT
Document Type and Number:
WIPO Patent Application WO/2023/045370
Kind Code:
A1
Abstract:
Provided is an antibody or an antigen-binding fragment thereof that binds to human TIGIT (T cell immunoreceptor with immunoglobulin and ITIM domains). Also provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a vector and host cell containing the nucleic acid molecule, an immunoconjugate and composition comprising the antibody or the antigen-binding fragment thereof, and the use of the antibody or the antigen-binding fragment thereof in the preparation of a product for positively adjusting the activity of immune cells and/or improving the immune response, a product for reducing or eliminating the immunosuppressive effect of cells expressing TIGIT (such as Treg cells), and a kit for detecting the presence or absence of TIGIT and the level or activity of TIGIT.
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Inventors:
CHEN YI (CN)
CAI ZELING (CN)
HE QIAOQIAO (CN)
WANG YALING (CN)
CAI ZELING (CN)
HE QIAOQIAO (CN)
WANG YALING (CN)
Application Number:
PCT/CN2022/094422
Publication Date:
March 30, 2023
Filing Date:
May 23, 2022
Export Citation:
Assignee:
SHANGHAI CELGEN BIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P31/00; A61P35/00; A61P37/04; C07K16/46; C12N5/16; C12N15/13; C12N15/63; G01N33/577
Foreign References:
| CN110352200A | 2019-10-18 | |||
| CN109071620A | 2018-12-21 | |||
| CN107148430A | 2017-09-08 | |||
| CN109734806A | 2019-05-10 | |||
| CN112274637A | 2021-01-29 | |||
| CN112794909A | 2021-05-14 | |||
| US4816567A | 1989-03-28 |
Other References:
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BOEHMER, L. ET AL.: "Sequencing and cloning of antigen-specific antibodies from mouse memory B cells", NAT PROTOC, vol. 11, no. 10, 2016, pages 1908 - 1923
RUDD C E.: "The reverse stop-signal model for CTLA4 function", NAT REV IMMUNOL, vol. 8, 2008, pages 153 - 160
MERCIER ET AL., FRONT. IMMUNOL., vol. 6, 2015, pages 418
YU ET AL., NAT. IMMUNOL., vol. 10, 2009, pages 48 - 57
MARTINET ET AL., NAT. REV. IMMUNOL., vol. 15, 2015, pages 243 - 254
FOURCADE J. ET AL., JCI INSIGHT, vol. 3, no. 14, 2018, pages el21157
LI ET AL., J BIOL. CHEM., vol. 289, 2014, pages 17647 - 17657
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
"Tissue Culture", 1973, ACADEMIC PRESS
MUNSON ET AL., ANAL. BIOCHEM., vol. 107, 1980, pages 220
"Molecular Cloning Experiment Guide", 1989, COLD SPRING HARBOR LABORATORY PRESS
BOEHMER, L. ET AL.: "Sequencing and cloning of antigen-specific antibodies from mouse memory B cells", NAT PROTOC, vol. 11, no. 10, 2016, pages 1908 - 1923
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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