MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING

WIPO Patent Application WO/2010/054330

A3

The present invention provides symmetric carbocyanine dyes and dye precursors useful for fluorescence microscopy, and methods of making and using same.

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HILDERBRAND SCOTT A (US)
WEISSLEDER RALPH (US)
SHAO FANGWEI (US)

PCT/US2009/063750

September 30, 2010

November 09, 2009

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GEN HOSPITAL CORP (US)
HILDERBRAND SCOTT A (US)
WEISSLEDER RALPH (US)
SHAO FANGWEI (US)

C07D235/20; C07D209/18; C07D235/06; C09B23/02

US20070203343A1	2007-08-30
US20020064794A1	2002-05-30

HILDERBRAND A. SCOTT ET AL.: "Optimized pH-responsive cyanine fluorochromes for detection of acidic environments", CHEM. COMMUN., 2007, pages 2747 - 2749
LIN YUHUI ET AL.: "Novel Near-Infrared Cyanine Fluorochromes; Synthesis, prop erties and Bioconjugation", BIOCONJUGATE CHEM., vol. 13, 2002, pages 605 - 610
MUJUMDAR R. SWATI ET AL.: "Cyanine-Labeling Reagents;Sulfobenzindocyanine Succ inimidyl Esters", BIOCONJUGATE CHEM., vol. 7, 1996, pages 356 - 362
SHAO FANGWEI ET AL.: "Monofunctional Carbocyanine Dyes for Bio- and Bioorthog onal Conjugation", BIOCONJU.CHEM., vol. 19, no. 12, 20 November 2008 (2008-11-20), pages 2487 - 2491

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