Title:
MONOOXYGENASE MUTANT AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/093191
Kind Code:
A1
Abstract:
Provided are a monooxygenase mutant and an application thereof. The amino acid sequence of the monooxygenase mutant is a mutated version of the amino acid sequence shown in SEQ ID NO: 1. The mutation comprises a mutation at at least one of the following sites: 45, 95, 106, 108, 114, 186, 190, 191, 249, 257, 393, 436, 499, 500, 501, 503, 504, 559, and 560.
Inventors:
HONG HAO (CN)
JAMES GAGE (CN)
LU JIANGPING (CN)
JIAO XUECHENG (CN)
ZHANG NA (CN)
ZHANG KEJIAN (CN)
LI RUI (CN)
ZHANG YU (CN)
YANG YIMING (CN)
JAMES GAGE (CN)
LU JIANGPING (CN)
JIAO XUECHENG (CN)
ZHANG NA (CN)
ZHANG KEJIAN (CN)
LI RUI (CN)
ZHANG YU (CN)
YANG YIMING (CN)
Application Number:
PCT/CN2018/113938
Publication Date:
May 14, 2020
Filing Date:
November 05, 2018
Export Citation:
Assignee:
ASYMCHEM LAB TIANJIN CO LTD (CN)
International Classes:
C12N9/02; C12N15/53; C12P11/00
Foreign References:
| CN108300707A | 2018-07-20 | |||
| CN106754802A | 2017-05-31 | |||
| CN105695425A | 2016-06-22 |
Other References:
DATABASE Protein 17 October 2001 (2001-10-17), ANONYMOUS: "Cyclododecanone monooxygenase [Rhodococcus ruber]", XP055706211, retrieved from NCBI Database accession no. AAL14233
LIANG QIULING , SHENG WU : "Nonconserved Hinge in Baeyer-Villiger Monooxygenase Affects Catalytic Activity and Stereoselectivity", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 31, no. 3, 25 March 2015 (2015-03-25), pages 361 - 374, XP055805545, DOI: 10.13345/j.cjb.140297
CHEM. REV., vol. 111, 2011, pages 4165 - 4222
See also references of EP 3878953A4
LIANG QIULING , SHENG WU : "Nonconserved Hinge in Baeyer-Villiger Monooxygenase Affects Catalytic Activity and Stereoselectivity", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 31, no. 3, 25 March 2015 (2015-03-25), pages 361 - 374, XP055805545, DOI: 10.13345/j.cjb.140297
CHEM. REV., vol. 111, 2011, pages 4165 - 4222
See also references of EP 3878953A4
Attorney, Agent or Firm:
KANGXIN PARTNERS,P.C. (CN)
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