Title:
MORPHINAN DERIVATIVE AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/190665
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent, an ameliorative agent, or a preventative agent that have kappa opioid receptor agonist activity and reduced side-effects and are for treating for various diseases relating to kappa opioid receptors. The present invention provides a morphinan derivative or a pharmacologically-acceptable acid addition salt thereof.
Inventors:
NOGAMI MARINA (JP)
NUMAJIRI YOSHITAKA (JP)
OMORI YU (JP)
ISHIHARA SAE (JP)
NUMAJIRI YOSHITAKA (JP)
OMORI YU (JP)
ISHIHARA SAE (JP)
Application Number:
PCT/JP2023/012763
Publication Date:
October 05, 2023
Filing Date:
March 29, 2023
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07D489/08; A61K31/485; A61P1/00; A61P1/16; A61P7/00; A61P9/00; A61P11/00; A61P13/00; A61P17/00; A61P25/00; A61P25/04; A61P25/36
Domestic Patent References:
| WO1995003308A1 | 1995-02-02 | |||
| WO1993015081A1 | 1993-08-05 | |||
| WO2013035833A1 | 2013-03-14 | |||
| WO2019189749A1 | 2019-10-03 |
Other References:
KOJI KAWAI, JUN HAYAKAWA, TORU MIYAMOTO, YOSHIFUMI IMAMURA, SHINICHI YAMANE, HISANORI WAKITA, HIDEAKI FUJII, KUNIAKI KAWAMURA, HIR: "Design, synthesis, and structure–activity relationship of novel opioid κ-agonists", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 20, 1 October 2008 (2008-10-01), AMSTERDAM, NL, pages 9188 - 9201, XP055566869, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2008.09.011
Download PDF: