Title:
MOSAIC INFLUENZA VIRUS HEMAGGLUTININ POLYPEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/246363
Kind Code:
A8
Abstract:
In one aspect, provided herein is a mosaic influenza virus hemagglutinin (HA) polypeptide comprising an influenza A virus HA ectodomain of an influenza A virus strain HA, wherein the HA ectodomain comprises an HA stem domain of the influenza A virus strain HA and an HA globular head domain of the influenza A virus strain HA, wherein the HA globular head domain of the influenza A virus strain HA has been engineered to comprise one or more amino acid substitutions in one, two, three, four or all of the antigenic sites. In another aspect, provided herein are immunogenic compositions comprising such a mosaic influenza virus HA polypeptide or an influenza A virus comprising such a mosaic influenza virus HA polypeptide. In yet another aspect, provided herein are methods for immunizing a subject against an influenza A virus in a subject comprising administering such an immunogenic composition to the subject.
Inventors:
GARCIA-SASTRE ADOLFO (US)
PALESE PETER (US)
KRAMMER FLORIAN (US)
BRÖCKER FELIX (DE)
SUN WEINA (US)
PALESE PETER (US)
KRAMMER FLORIAN (US)
BRÖCKER FELIX (DE)
SUN WEINA (US)
Application Number:
PCT/US2019/038178
Publication Date:
April 02, 2020
Filing Date:
June 20, 2019
Export Citation:
Assignee:
ICAHN SCHOOL MED MOUNT SINAI (US)
International Classes:
C07K14/005; A61K39/145; C12N15/63
Attorney, Agent or Firm:
CHHEDA, Jennifer, J. et al. (US)
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