Title:
MOUSE GASTRIC CANCER CELL LINE FOR EVALUATING EFFICACY AND TOXICITY OF IMMUNOTHERAPY AND OF THERAPEUTIC AGENT FOR GASTRIC CANCER
Document Type and Number:
WIPO Patent Application WO/2014/175567
Kind Code:
A1
Abstract:
The present invention relates to an animal model of naturally occurring gastric cancer for evaluating efficacy and toxicity of immunotherapy and a therapeutic agent for gastric cancer, or identifying a metastasis-suppressor gene and developing a metastasis suppressor, and a gastric cancer cell line established therefrom. Specifically, it has been observed that the animal model of gastric cancer and the gastric cancer cell line established therefrom according to the present invention exhibited histopathologic characteristics similar to those of human gastric cancer and the size of the cancer cell was reduced by a 4-1BB inhibitor having an anti-cancer activity; thus, the animal model of gastric cancer and the gastric cancer cell line established therefrom are useful for evaluating efficacy and toxicity of immunotherapy and a therapeutic agent for gastric cancer. One of the gastric cancer cell lines of the present invention metastasizes quickly and is thus useful for identifying genes associated with metastasis, developing a metastasis suppressor and evaluating efficacy thereof by comparing gene expression levels of the cell line and other cell lines. Accordingly, it has been proved that the animal model of gastric cancer and gastric cancer cell line of the present invention are useful for evaluating efficacy of a gastric cancer suppressor and a gastric cancer metastasis suppressor and evaluating immunotherapy, instead of immunosuppressed mice.
Inventors:
KIM HARK-KYUN (KR)
PARK JUN-WON (KR)
JANG SEOK-HOON (KR)
PARK JUN-WON (KR)
JANG SEOK-HOON (KR)
Application Number:
PCT/KR2014/002760
Publication Date:
October 30, 2014
Filing Date:
April 01, 2014
Export Citation:
Assignee:
NAT CANCER CT (KR)
International Classes:
A01K67/027; C12N5/16; G01N33/15
Foreign References:
| US20080242742A1 | 2008-10-02 | |||
| KR20130000331A | 2013-01-02 |
Other References:
KIM, HAK GYUN: "Study on Prediction of Chemosensitivity, Diagnostic Marker. Animal Model for Gastric Cancer", NATIONAL CANCER CENTER SUBJECT OF RESEARCH FINAL REPORT, 10 February 2012 (2012-02-10)
OLIVEIRA, CARLA ET AL., EUROPEAN JOURNAL OF CANCER, vol. 40, 25 June 2004 (2004-06-25), pages 1897 - 1903
TAKAKU, KAZUAKI ET AL., CANCER RESEARCH, vol. 59, 15 December 1999 (1999-12-15), pages 6113 - 6117
OLIVEIRA, CARLA ET AL., EUROPEAN JOURNAL OF CANCER, vol. 40, 25 June 2004 (2004-06-25), pages 1897 - 1903
TAKAKU, KAZUAKI ET AL., CANCER RESEARCH, vol. 59, 15 December 1999 (1999-12-15), pages 6113 - 6117
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
위병갑 (KR)
위병갑 (KR)
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