Title:
MR IMAGING DIAGNOSTIC AGENT FOR INTRACTABLE NEUROLOGICAL DISEASE
Document Type and Number:
WIPO Patent Application WO/2014/109296
Kind Code:
A1
Abstract:
Disclosed is a compound represented by formula (1) or a salt thereof.
In formula (1): X represents a residue of a compound having an activity to bind to at least one member selected from the group consisting of amyloid β protein, a tau protein, α-synuclein and TDP-43; m is an integer of 0 to 6; n is an integer of 1 to 5; and J is a group selected from the group consisting of (J-1), (J-2) and (J-3) [wherein R1
and R2 independently represent a hydrogen atom, a fluorine atom, methyl or trifluoromethyl; R3 represents trifluoromethyl or trifluoromethoxy; and p is an integer of 1 to 4, provided that when J is (J-1), m+n is not smaller than 5, and when J is (J-2) or (J-3), m+n is not smaller than 7.
Inventors:
TOOYAMA IKUO (JP)
TAGUCHI HIROYASU (JP)
YANAGISAWA DAIJIRO (JP)
TAGUCHI HIROYASU (JP)
YANAGISAWA DAIJIRO (JP)
Application Number:
PCT/JP2014/050005
Publication Date:
July 17, 2014
Filing Date:
January 06, 2014
Export Citation:
Assignee:
UNIV SHIGA MEDICAL SCIENCE (JP)
International Classes:
A61K49/00; C07C235/34; A61P25/28; C07D263/56
Domestic Patent References:
| WO2007111179A1 | 2007-10-04 | |||
| WO2010098502A1 | 2010-09-02 | |||
| WO2003106439A1 | 2003-12-24 | |||
| WO2005042461A1 | 2005-05-12 | |||
| WO2007111179A1 | 2007-10-04 | |||
| WO2010098502A1 | 2010-09-02 |
Foreign References:
| JP2009067762A | 2009-04-02 | |||
| JP2009067762A | 2009-04-02 |
Other References:
NEUROSCIENCE RESEARCH, vol. 63, no. 1, 2009, pages 76 - 81, XP025803704
KLUNK WE; ENGLER H; NORDBERG A ET AL.: "Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B", ANN NEUROL, vol. 55, 2004, pages 306 - 319, XP008031485, DOI: doi:10.1002/ana.20009
OKAMURA N; SUEMOTO T; SHIMADZU H; SUZUKI M; SHIOMITSU T; AKATSU H; YAMAMOTO T; STAUFENBIEL M; YANAI K; ARAI H: "Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain", J NEUROSCI, vol. 24, no. 10, 2004, pages 2535 - 41, XP003015010, DOI: doi:10.1523/JNEUROSCI.4456-03.2004
FURUKAWA K; OKAMURA N; TASHIRO M; WARAGAI M; FURUMOTO S; IWATA R; YANAI K; KUDO Y; ARAI H: "Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET", J NEUROL, vol. 257, 2010, pages 721 - 727, XP019847751
HIGUCHI M; IWATA N; MATSUBA Y; SATO K; SASAMOTO K; SAIDO T: "F and H MRI detection of amylid ? plaques in vivo", NATURE NEUROSCIENCE, vol. 8, no. 4, 2005, pages 527 - 533
N. OKAMURA ET AL., J NUCL MED, vol. 54, no. 8, 2013, pages 1420 - 1427
D.T. CHIEN ET AL., JOURNAL OF ALZHEIMER'S DISEASE
K.L. NEAL ET AL., MOL IMAGING BIOL, 2013
See also references of EP 2944626A4
KLUNK WE; ENGLER H; NORDBERG A ET AL.: "Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B", ANN NEUROL, vol. 55, 2004, pages 306 - 319, XP008031485, DOI: doi:10.1002/ana.20009
OKAMURA N; SUEMOTO T; SHIMADZU H; SUZUKI M; SHIOMITSU T; AKATSU H; YAMAMOTO T; STAUFENBIEL M; YANAI K; ARAI H: "Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain", J NEUROSCI, vol. 24, no. 10, 2004, pages 2535 - 41, XP003015010, DOI: doi:10.1523/JNEUROSCI.4456-03.2004
FURUKAWA K; OKAMURA N; TASHIRO M; WARAGAI M; FURUMOTO S; IWATA R; YANAI K; KUDO Y; ARAI H: "Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET", J NEUROL, vol. 257, 2010, pages 721 - 727, XP019847751
HIGUCHI M; IWATA N; MATSUBA Y; SATO K; SASAMOTO K; SAIDO T: "F and H MRI detection of amylid ? plaques in vivo", NATURE NEUROSCIENCE, vol. 8, no. 4, 2005, pages 527 - 533
N. OKAMURA ET AL., J NUCL MED, vol. 54, no. 8, 2013, pages 1420 - 1427
D.T. CHIEN ET AL., JOURNAL OF ALZHEIMER'S DISEASE
K.L. NEAL ET AL., MOL IMAGING BIOL, 2013
See also references of EP 2944626A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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