Title:
MRNA FUNCTIONALIZATION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/124181
Kind Code:
A1
Abstract:
The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
Inventors:
UCHIDA SATOSHI (JP)
ITAKA KEIJI (JP)
KATAOKA KAZUNORI (JP)
YOSHINAGA NAOTO (JP)
ITAKA KEIJI (JP)
KATAOKA KAZUNORI (JP)
YOSHINAGA NAOTO (JP)
Application Number:
PCT/JP2017/046906
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
UNIV TOKYO (JP)
KAWASAKI INST OF INDUSTRIAL PROMOTION (JP)
KAWASAKI INST OF INDUSTRIAL PROMOTION (JP)
International Classes:
C12N15/117; A61K31/7088; A61K31/7115; A61K39/00; A61K47/50; A61K48/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P37/04; C12N15/11
Domestic Patent References:
| WO2015121924A1 | 2015-08-20 | |||
| WO2015121924A1 | 2015-08-20 |
Foreign References:
| JP2010540500A | 2010-12-24 | |||
| JP2012502074A | 2012-01-26 | |||
| JP2012502074A | 2012-01-26 | |||
| JP2016252487A | 2016-12-27 | |||
| JP2016252488A | 2016-12-27 |
Other References:
UCHIDA, S. ET AL.: "Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination", BIOMATERIALS, vol. 150, 27 September 2017 (2017-09-27), pages 162 - 170, XP085246319, ISSN: 0142-9612
MEIS, J. E.CHEN, F., EPICENTRE FORUM, vol. 9, no. 1, 2002, pages 10
UCHIDA, S. ET AL., BIOMATERIALS, vol. 82, 2016, pages 221 - 228
KARL-JOSEF KALLEN ET AL., HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 9, no. 10, 2013, pages 2263 - 2276
OSAWA, S. ET AL., BIOMACROMOLECULES, vol. 17, 2016, pages 354 - 361
OBA, M. ET AL., BIOMATERIALS, vol. 32, 2011, pages 3106 - 3114
MIYATA, K. ET AL., BIOMATERIALS, vol. 31, 2010, pages 4764 - 4770
BLOOD, vol. 108, no. 13, 2006, pages 4009 - 17
ALTZSHUL S.F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
S. L. BEAUCAGE ET AL., TETRAHEDRON LETTERS, vol. 22, 1981, pages 1859 - 1862
M. OISHI ET AL., CHEM BIO CHEM, vol. 6, no. 4, 2005, pages 718 - 725
K. OSADA ET AL., BIOMATERIALS, vol. 33, 2012, pages 325 - 332
See also references of EP 3564375A4
MEIS, J. E.CHEN, F., EPICENTRE FORUM, vol. 9, no. 1, 2002, pages 10
UCHIDA, S. ET AL., BIOMATERIALS, vol. 82, 2016, pages 221 - 228
KARL-JOSEF KALLEN ET AL., HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 9, no. 10, 2013, pages 2263 - 2276
OSAWA, S. ET AL., BIOMACROMOLECULES, vol. 17, 2016, pages 354 - 361
OBA, M. ET AL., BIOMATERIALS, vol. 32, 2011, pages 3106 - 3114
MIYATA, K. ET AL., BIOMATERIALS, vol. 31, 2010, pages 4764 - 4770
BLOOD, vol. 108, no. 13, 2006, pages 4009 - 17
ALTZSHUL S.F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
S. L. BEAUCAGE ET AL., TETRAHEDRON LETTERS, vol. 22, 1981, pages 1859 - 1862
M. OISHI ET AL., CHEM BIO CHEM, vol. 6, no. 4, 2005, pages 718 - 725
K. OSADA ET AL., BIOMATERIALS, vol. 33, 2012, pages 325 - 332
See also references of EP 3564375A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Download PDF: