Title:
MUCUS ADHESION DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2022/160228
Kind Code:
A1
Abstract:
It relates to a mucus adhesion drug delivery technology. The technology involves the preparation of materials consisting of mucus adhesive excipient polymer chemically bonded with drug molecules and delivery of the materials with fast disintegration tablet with enteric coating to intestine. The bonding between the excipient polymer and the drug molecules is either ionic bonds, covalent bonds, or metal coordination bonds. The test of the mucus adhesion drug delivery technology was carried out using a dog model. The test data indicated successful retaining of drug molecules on the intestine mucus resulting in not only dramatic extension of drug release time, but also great improvement in the bioavailability of the API.
Inventors:
SUN YIMIN (CN)
Application Number:
PCT/CN2021/074312
Publication Date:
August 04, 2022
Filing Date:
January 29, 2021
Export Citation:
Assignee:
SUN YIMIN (CN)
International Classes:
A61K47/30; A61K9/20; A61K9/22
Domestic Patent References:
| WO2000025823A1 | 2000-05-11 | |||
| WO2009008006A2 | 2009-01-15 |
Foreign References:
| US20120027855A1 | 2012-02-02 | |||
| JP2018021000A | 2018-02-08 |
Other References:
SOGIAS IOANNIS A., WILLIAMS ADRIAN C., KHUTORYANSKIY VITALIY V.: "Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 436, no. 1-2, 1 October 2012 (2012-10-01), NL , pages 602 - 610, XP055954820, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2012.07.007
M. WAYS TWANA, LAU WING, KHUTORYANSKIY VITALIY: "Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems", POLYMERS, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (M DP I) AG., CH, vol. 10, no. 3, 1 March 2018 (2018-03-01), CH , pages 267 - 37, XP055954824, ISSN: 2073-4360, DOI: 10.3390/polym10030267
M. WAYS TWANA, LAU WING, KHUTORYANSKIY VITALIY: "Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems", POLYMERS, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (M DP I) AG., CH, vol. 10, no. 3, 1 March 2018 (2018-03-01), CH , pages 267 - 37, XP055954824, ISSN: 2073-4360, DOI: 10.3390/polym10030267
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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