Title:
MULTI-BLOCK COPOLYPEPTIDE, WHICH IS COMPOSED OF ELASTIN-BASED PEPTIDE AND MUSSEL FOOT PROTEIN AND HAS STIMULUS RESPONSIVITY AND SURFACE ADHESIVENESS, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/186702
Kind Code:
A1
Abstract:
The present invention relates to a multi-block copolypeptide having stimulus responsivity and surface adhesiveness. When the multi-block copolypeptide composed of an elastin-based peptide and a mussel foot protein, of the present invention, is used, a self-assembled core-shell structure and a hydrogel, both of which can be reversibly changed according to temperature stimuli, can be formed, and the multi-block copolypeptide has remarkably excellent surface adhesiveness, thereby being usable in the field of biomedical applications.
Inventors:
LIM DONG WOO (KR)
LEE JAE HEE (KR)
LEE JAE SANG (KR)
LEE JAE HEE (KR)
LEE JAE SANG (KR)
Application Number:
PCT/KR2018/004029
Publication Date:
October 11, 2018
Filing Date:
April 05, 2018
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07K14/435; A61F2/82; A61K9/107; A61L31/04; C07K14/78
Domestic Patent References:
| WO2015116665A2 | 2015-08-06 |
Foreign References:
| US20160220727A1 | 2016-08-04 | |||
| KR101722503B1 | 2017-04-04 |
Other References:
YOSHIKI, ITO: "Genetically engineered synthesis of artificial proteins incorporated with adhesive functional amino acid residues into repetitive sequence of elastin", POLYMER PREPRINTS, vol. 53, no. 2, 2010, Retrieved from the Internet
ROBERTS, S.: "Elastin-like polypeptides as models of intrinsically disordered proteins", FEBS LETTERS, vol. 589, 2015, pages 2477 - 2486, XP029279392, doi:10.1016/j.febslet.2015.08.029
"Molecular design and characterization of fusion proteins with temperature responsiveness and surface adhesion'' 3PS-262"
LEE, J. H, CO-EXPRESSION OF STIMULI-RESPONSIVE AND SURFACE-ADHESIVE FUS ION PROTEINS WITH TYROSINE HYDROXYLASE IN E. COLI
ROBERTS, S.: "Elastin-like polypeptides as models of intrinsically disordered proteins", FEBS LETTERS, vol. 589, 2015, pages 2477 - 2486, XP029279392, doi:10.1016/j.febslet.2015.08.029
"Molecular design and characterization of fusion proteins with temperature responsiveness and surface adhesion'' 3PS-262"
LEE, J. H, CO-EXPRESSION OF STIMULI-RESPONSIVE AND SURFACE-ADHESIVE FUS ION PROTEINS WITH TYROSINE HYDROXYLASE IN E. COLI
Attorney, Agent or Firm:
DAHAI INTERNATIONAL PATENT & LAW FIRM (KR)
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