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Patent Searching and Data


Title:
MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/076614
Kind Code:
A3
Abstract:
The present disclosure provides pyrazolo[1,5-a]pyrimidine compounds and compositions comprising the same which inhibit IRAK and/or FLT3. The present disclosure further provides methods of using the pyrazolo[1,5-a]pyrimidine compounds to treat a disease or disorder such as a hematopoietic cancer, myelodysplastic syndromes (MDS), or acute myeloid leukemia (AML). Additional embodiments provide disease treatment using combinations of the disclosed IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Inventors:
HOYT SCOTT (US)
STARCZYNOWSKI DANIEL (US)
THOMAS CRAIG (US)
ROSENBAUM JAN (US)
Application Number:
PCT/US2023/034438
Publication Date:
May 16, 2024
Filing Date:
October 04, 2023
Export Citation:
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Assignee:
CHILDRENS HOSPITAL MED CT (US)
THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVIC (US)
KUROME THERAPEUTICS INC (US)
International Classes:
A61K31/519; C07D487/04
Attorney, Agent or Firm:
FRAIND, Alicia, M. et al. (US)
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