Title:
MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/076614
Kind Code:
A3
Abstract:
The present disclosure provides pyrazolo[1,5-a]pyrimidine compounds and compositions comprising the same which inhibit IRAK and/or FLT3. The present disclosure further provides methods of using the pyrazolo[1,5-a]pyrimidine compounds to treat a disease or disorder such as a hematopoietic cancer, myelodysplastic syndromes (MDS), or acute myeloid leukemia (AML). Additional embodiments provide disease treatment using combinations of the disclosed IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.
More Like This:
| JP2024507294 | Method of treatment |
| WO/2022/106984 | SMALL MOLECULE INHIBITORS OF SARS-COV2 MAIN PROTEASE |
| JP2014513103 | Compositions and methods |
Inventors:
HOYT SCOTT (US)
STARCZYNOWSKI DANIEL (US)
THOMAS CRAIG (US)
ROSENBAUM JAN (US)
STARCZYNOWSKI DANIEL (US)
THOMAS CRAIG (US)
ROSENBAUM JAN (US)
Application Number:
PCT/US2023/034438
Publication Date:
May 16, 2024
Filing Date:
October 04, 2023
Export Citation:
Assignee:
CHILDRENS HOSPITAL MED CT (US)
THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVIC (US)
KUROME THERAPEUTICS INC (US)
THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVIC (US)
KUROME THERAPEUTICS INC (US)
International Classes:
A61K31/519; C07D487/04
Attorney, Agent or Firm:
FRAIND, Alicia, M. et al. (US)
Download PDF:
Previous Patent: EXTERNAL SCREEN STREAMING FOR AN EYEWEAR DEVICE
Next Patent: CHUTE ROTATION CONTROL SYSTEM FOR SNOW THROWER
Next Patent: CHUTE ROTATION CONTROL SYSTEM FOR SNOW THROWER